1-甲基-4-苯基乙炔苯合成路线 （共 165 条）
反应条件
1: (i) HCl, (ii) SO2Cl2, (iii) MCPBA 2: aq. NaOH / dioxane View Scheme
参考文献
Paquette,L.A.; Wittenbrook,L.S.
Journal of the American Chemical Society, 1967 , vol. 89, # 17 p. 4483 - 4487
反应条件
C16H28Cl2NPPd; caesium carbonate in N,N-dimethyl-formamide T=95°C; Sonogashira Cross-Coupling; Inert atmosphere;
参考文献
Buxaderas, Eduardo; Alonso, Diego A.; Najera, Carmen
European Journal of Organic Chemistry, 2013 , # 26 p. 5864 - 5870
反应条件
(i) nBuLi, Et2O, THF, PE, (ii) CO2; Multistep reaction;
参考文献
Mouries, Virginie; Waschbuesch, Rachel; Carran, John; Savignac, Philippe
Synthesis, 1998 , # 3 p. 271 - 274
反应条件
copper; zinc; bis(cyclopentadienyl)titanium dichloride; bis-triphenylphosphine-palladium(II) chloride in ethylene glycol dimethyl ether T=65°C; 2 h;
参考文献
Tamaru, Yoshinao; Ochiai, Hirofumi; Yoshida, Zen-ichi
Tetrahedron Letters, 1984 , vol. 25, # 35 p. 3861 - 3864
反应条件
in tetrahydrofuran; toluene T=-45 - 20°C;
参考文献
Katritzky, Alan R.; Abdel-Fattah, Ashraf A. A.; Wang, Mingyi
Journal of Organic Chemistry, 2002 , vol. 67, # 21 p. 7526 - 7529
反应条件
2,6-dimethylpyridine; 1,10-phenanthroline; oxygen in methanol T=20°C;
参考文献
Verna, Florian; Guissart, Celine; Pous, Jonathan; Evano, Gwilherm
Monatshefte fur Chemie, 2013 , vol. 144, # 4 p. 523 - 529
反应条件
palladium diacetate; dimethyl sulfoxide T=35°C; Sonogashira Cross-Coupling; 1 h;
参考文献
Barbero, Margherita; Cadamuro, Silvano; Dughera, Stefano
European Journal of Organic Chemistry, 2014 , vol. 2014, # 3 p. 598 - 605
反应条件
potassium tert-butylate in N,N-dimethyl-formamide T=85°C;
参考文献
Katritzky, Alan R.; Gordeev, Mikhail F.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1992 , # 11 p. 1295 - 1298
反应条件
bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; tributyl-amine; potassium carbonate in water 1.5 h; Ambient temperature;
参考文献
Sukhomlinova, L. I.; Luzikova, E. V.; Tolstaya, T. P.; Bumagin, N. A.; Beletskaya, I. P.
Russian Chemical Bulletin, 1995 , vol. 44, # 4 p. 769 - 770
Izvestiya Akademi Nauk, Seriya Khimicheskaya, 1995 , # 4 p. 789
反应条件
palladium dichloride in water; acetonitrile 1 h; Ambient temperature;
参考文献
Kang, Suk-Ku; Lee, Hong-Woo; Jang, Su-Bum; Kim, Tae-Hyun; Kim, Jae-Sun
Synthetic Communications, 1996 , vol. 26, # 23 p. 4311 - 4318
