1-甲基-4-苯基乙炔苯合成路线 （共 165 条）
反应条件
palladium diacetate; triphenylphosphine in N,N-dimethyl acetamide T=80°C; P=760 Torr; 1 h;
参考文献
Kakusawa, Naoki; Kurita, Jyoji
Chemical and Pharmaceutical Bulletin, 2006 , vol. 54, # 5 p. 699 - 702
反应条件
pyrrolidine; triphenylphosphine; 1-n-butyl-3-methylimidazolium hexafluorophosphate; bis(η3-allyl-μ-chloropalladium(II)) T=130°C; Heck alkynylation; 20 h;
参考文献
Hierso, Jean-Cyrille; Boudon, Julien; Picquet, Michel; Meunier, Philippe
European Journal of Organic Chemistry, 2007 , # 4 p. 583 - 587
反应条件
1: silver(I) acetate / N,N-dimethyl-formamide / 46 h / 80 °C / Darkness 2: Cu(I) 3-methylsalicylate; bis(dibenzylideneacetone)-palladium(0) / N,N-dimethyl-formamide / 22 h / 45 - 50 °C View Scheme
参考文献
Peng, Lifen; Xu, Feng; Suzuma, Yoshinori; Orita, Akihiro; Otera, Junzo
Journal of Organic Chemistry, 2013 , vol. 78, # 24 p. 12802 - 12808
反应条件
tetrakis(triphenylphosphine) palladium(0) T=80°C; Stille cross-coupling; 13 h; Ionic liquidInert atmosphere;
参考文献
Hao, Wenyan; Xi, Zhiwen; Cai, Mingzhong
Synthetic Communications, 2012 , vol. 42, # 16 p. 2396 - 2406
反应条件
1,3-dimethyl-imidazolidin-2-one; potassium carbonate; triphenylphosphine; copper(l) chloride T=120°C; 12 h;
参考文献
Ogawa, Daisuke; Li, Jing; Suetsugu, Masato; Jiao, Jiao; Iwasaki, Masayuki; Nishihara, Yasushi
Tetrahedron Letters, 2013 , vol. 54, # 6 p. 518 - 521
反应条件
copper(l) iodide; 8-hydroxy-quinoline; potassium carbonate in N,N-dimethyl-formamide T=110°C; 48 h; Inert atmosphere;
参考文献
Yan, Hong; Lu, Linhua; Sun, Peng; Zhu, Yan; Yang, Hailong; Liu, Defu; Rong, Guangwei; Mao, Jincheng
RSC Advances, 2013 , vol. 3, # 2 p. 377 - 381
反应条件
1: 1-chloro-4-bromobenzene; Na(1+)*Al(CCC6H5)4(1-)=NaAl(CCC6H5)4 With bis-triphenylphosphine-palladium(II) chloride in tetrahydrofuran 7 h; Heating; 2: (CH3)2AlOC2H4N(CH3)2 With NiCl2((PPh3)P)2 in tetrahydrofuran 12 h; Heating; Further stages.;
参考文献
Gelman, Dmitri; Tsvelikhovsky, Dmitry; Molander, Gary A.; Blum, Jochanan
Journal of Organic Chemistry, 2002 , vol. 67, # 18 p. 6287 - 6290
反应条件
copper(l) iodide; triethylamine; bis(benzonitrile)palladium(II) dichloride in tetrahydrofuran Sonogashira-Hagihara cross-coupling; Heating; Product distribution; Further Variations:CatalystsReagentsSolvents;
参考文献
Dubbaka, Srinivas Reddy; Vogel, Pierre
Advanced Synthesis and Catalysis, 2004 , vol. 346, # 13-15 p. 1793 - 1797
反应条件
1: 95 percent / KOH View Scheme
参考文献
Buxaderas, Eduardo; Alonso, Diego A.; Najera, Carmen
European Journal of Organic Chemistry, 2013 , # 26 p. 5864 - 5870
反应条件
1: iodobenzene; 2-methyl-but-3-yn-2-ol With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; diisopropylamine T=50°C; 1 h; Inert atmosphere; 2: 1-(iodo)-4-methylbenzene With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; potassium hydroxide T=110°C; 5 h; Inert atmosphere;
参考文献
Zhao, Yankai; Liu, Qiang; Li, Jing; Liu, Zhongquan; Zhou, Bo
Synlett, 2010 , # 12 p. 1870 - 1872
