2-乙酰氨基-5-巯基-1,3,4-噻二唑合成路线 （共 8 条）
反应条件
1: With potassium hydroxide in ethanol T=20 - 30°C; 4.5 h; 2: With sulfuric acid in ethanol T=0 - 20°C; 2 h;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 23, # 13 p. 3723 - 3727
参考文献
Talath; Gadad
European Journal of Medicinal Chemistry, 2006 , vol. 41, # 8 p. 918 - 924
反应条件
chlorine; acetic acid T=0 - 2°C; 2 h;
参考文献
Talath; Gadad
European Journal of Medicinal Chemistry, 2006 , vol. 41, # 8 p. 918 - 924
反应条件
sodium hydroxide; sodium hypochlorite; acetic anhydride; acetic acid; 3-chloro-benzenecarboperoxoic acid in ethylene glycol dimethyl ether; water; sodium carbonate; 5-amino-2-mercapto-1,3,4-thiadiazole
参考文献
University of Iowa Research Foundation
Patent: US4483864 A1, 1984 ;
参考文献
Cristescu,C.; Marcus,J.
Pharmazie, 1961 , vol. 16, p. 135 - 137
反应条件
hydrogenchloride; dihydrogen peroxide; acetic acid
T=10 - 15°C; 8 h;
参考文献
Loghmani-Khouzani, Hossein; Rauckyte, Teresa; Osmialowski, Borys; Gawinecki, Ryszard; Kolehmainen, Erkki
Phosphorus, Sulfur and Silicon and the Related Elements, 2007 , vol. 182, # 9 p. 2217 - 2225
参考文献
Young et al.
Journal of the American Chemical Society, 1956 , vol. 78, p. 4649,4652
