2-氨基-5-氯-1,4-苯二甲酸合成路线 （共 4 条）
反应条件
1: With potassium hydroxide in tetrahydrofuran; water 48 h; Reflux; 2: With hydrogenchloride in water T=0°C;
参考文献
Angewandte Chemie - International Edition, , vol. 50, # 51 p. 12193 - 12196
反应条件
1.1: N-chloro-succinimide / isopropyl alcohol / 24 h / 85 °C 2.1: potassium hydroxide / tetrahydrofuran; water / 48 h / Reflux 2.2: 0 °C View Scheme
参考文献
Angewandte Chemie - International Edition, , vol. 50, # 51 p. 12193 - 12196
反应条件
thionyl chloride T=20°C; Cooling with ice;
参考文献
GLAXOSMITHKLINE LLC; SCHULZ, Mark, James; WANG, Yonghui
Patent: WO2010/59549 A1, 2010 ;
Location in patent: Page/Page column 25-26 ;
WO 2010/059549 A1
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2004/80970 A1, 2004 ;
Location in patent: Page 47; 48 ;
WO 2004/080970 A1
