3,5,6-三氯-4-肼吡啶-2-羧酸合成路线 （共 5 条）
反应条件
sodium hydroxide; hydrazine in water 1.66667 h; Reflux;
参考文献
ARDEA BIOSCIENCES INC.
Patent: WO2009/89263 A2, 2009 ;
Location in patent: Page/Page column 111-112 ;
反应条件
sulfuric acid in water
参考文献
The Dow Chemical Company
Patent: US4087431 A1, 1978 ;
反应条件
sulfuric acid; hydrazine; water; triethylamine 1.) C2H5OH, reflux, 1 h; Multistep reaction. Title compound not separated from byproducts;
参考文献
Sipyagin, A. M.; Aliev, Z. G.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1993 , vol. 29, # 11 p. 1287 - 1290
Khimiya Geterotsiklicheskikh Soedinenii, 1993 , # 11 p. 1495 - 1498
反应条件
1: With sodium hypochlorite; water; sodium hydroxide T=30°C; 2: With hydrogenchloride in water pH=2;
参考文献
ARDEA BIOSCIENCES INC.
Patent: WO2009/89263 A2, 2009 ;
Location in patent: Page/Page column 111-112 ;
反应条件
hydrogenchloride; sodium hydroxide in dichloromethane; water
参考文献
The Dow Chemical Company
Patent: US4087431 A1, 1978 ;
