6-硝基-4-(三氟甲基)喹啉-2(1h)-酮合成路线 （共 4 条）
反应条件
sulfuric acid; nitric acid T=-5 - 10°C; 1 h;
参考文献
Van Oeveren, Arjan; Motamedi, Mehrnouch; Mani, Neelakandha S.; Marschke, Keith B.; Lopez, Francisco J.; Schrader, William T.; Negro-Vilar, Andres; Zhi, Lin
Journal of Medicinal Chemistry, 2006 , vol. 49, # 21 p. 6143 - 6146
反应条件
1: toluene; H2O / 21 h / 130 °C / Heating 2: 63.4 g / H2SO4 / 1.5 h / 80 - 90 °C 3: 93 percent / H2SO4; aq. HNO3 / 1 h / -5 - 10 °C View Scheme
参考文献
Van Oeveren, Arjan; Motamedi, Mehrnouch; Mani, Neelakandha S.; Marschke, Keith B.; Lopez, Francisco J.; Schrader, William T.; Negro-Vilar, Andres; Zhi, Lin
Journal of Medicinal Chemistry, 2006 , vol. 49, # 21 p. 6143 - 6146
反应条件
1: 63.4 g / H2SO4 / 1.5 h / 80 - 90 °C 2: 93 percent / H2SO4; aq. HNO3 / 1 h / -5 - 10 °C View Scheme
参考文献
Van Oeveren, Arjan; Motamedi, Mehrnouch; Mani, Neelakandha S.; Marschke, Keith B.; Lopez, Francisco J.; Schrader, William T.; Negro-Vilar, Andres; Zhi, Lin
Journal of Medicinal Chemistry, 2006 , vol. 49, # 21 p. 6143 - 6146
反应条件
hydrogen; palladium on activated charcoal in ethanol 96 h;
参考文献
Van Oeveren, Arjan; Motamedi, Mehrnouch; Mani, Neelakandha S.; Marschke, Keith B.; Lopez, Francisco J.; Schrader, William T.; Negro-Vilar, Andres; Zhi, Lin
Journal of Medicinal Chemistry, 2006 , vol. 49, # 21 p. 6143 - 6146
