3,4-二溴噻吩-2-羧醛合成路线 （共 5 条）
反应条件
1: With lithium diisopropyl amide in tetrahydrofuran T=-78°C; Inert atmosphere; 2: With N,N-dimethyl-formamide T=20°C;
参考文献
Deng, Huayun; Hu, Jieyu; Hu, Haibei; He, Mingqian; Fang, Ye
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 12 p. 4148 - 4152
反应条件
n-butyllithium in diethyl ether; N,N-dimethyl-formamide
参考文献
Ortho Pharmaceutical Corporation
Patent: US5621113 A1, 1997 ;
US 5621113 A
反应条件
acetic acid; lithium diisopropyl amide in tetrahydrofuran; N-methyl-acetamide; water
参考文献
Agejas-Chicharro, Javier; Belen Bueno Melendo, Ana; Camp, Nicholas Paul; Gilmore, Jeremy; Jimenez-Aguado, Alma Maria; Lamas-Peteira, Carlos; Marcos-Llorente, Alicia; Mazanetz, Michael Philip; Montero Salgado, Carlos; Timms, Graham Henry; Williams, Andrew Caerwyn
Patent: US2004/122001 A1, 2004 ;
US 20040122001 A1
反应条件
titanium tetrachloride
参考文献
Gromova, G. P.; Belen'kii, L. I.; Krayushkin, M. M.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1993 , vol. 29, # 8 p. 889 - 891
Khimiya Geterotsiklicheskikh Soedinenii, 1993 , # 8 p. 1046 - 1048
反应条件
1.1: sodium hydride / N,N-dimethyl-formamide / 0.08 h / 0 °C / Inert atmosphere 1.2: 16 h / -30 - 20 °C / Inert atmosphere 2.1: potassium carbonate / methanol / 12 h / 0 - 20 °C / Inert atmosphere 3.1: gold(I) chloride / 1,4-dioxane; water / 3 h / 20 °C / Inert atmosphere View Scheme
参考文献
Yamamoto, Takuya; Katsuta, Hiroshi; Toyota, Kozo; Iwamoto, Takeaki; Morita, Noboru
Bulletin of the Chemical Society of Japan, 2012 , vol. 85, # 5 p. 613 - 623
