1-甲基-5-硝基-2(1H)-吡啶酮合成路线 （共 17 条）
反应条件
1: 2-hydroxy-5-nitro-pyridine With sodium hydride in N,N-dimethyl-formamide T=0°C; 0.5 h; 2: methyl iodide in N,N-dimethyl-formamide T=0 - 20°C;
参考文献
XCOVERY HOLDING COMPANY, LLC; LIANG, Congxin
Patent: WO2012/48258 A2, 2012 ;
Location in patent: Page/Page column 32 ;
WO 2012/048258 A2
反应条件
1: 5-nitro-1,2-dihydropyridin-2-one With sodium hydride in N,N-dimethyl-formamide T=0°C; 0.5 h; 2: methyl iodide in N,N-dimethyl-formamide T=0 - 20°C; 1 h;
参考文献
WO2012/48258 A2, ;
Page/Page column 32 ;
WO 2012/048258 A2
反应条件
sodium hydroxide in water T=25°C;
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED
Patent: WO2005/99688 A2, 2005 ;
Location in patent: Page/Page column 140 ;
WO 2005/099688 A2
反应条件
T=600°C; P=0.01 Torr;
参考文献
Australian Journal of Chemistry, , vol. 56, # 9 p. 913 - 916
反应条件
T=100°C; Hilbert-Johnson reaction; P=6000600 Torr; 48 h;
参考文献
Iida, Hirokazu; Suda, Machiko; Nakajima, Etsuko; Hakamatsuka, Hiroko; Nagashima, Yuka; Joho, Kouta; Amemiya, Kenta; Moromizato, Tatsuya; Matsumoto, Kiyoshi; Murakami, Yasuoki; Hamana, Hiroshi
Heterocycles, 2010 , vol. 81, # 9 p. 2057 - 2062
反应条件
T=100°C; Hilbert-Johnson reaction; P=6000600 Torr; 72 h;
参考文献
Heterocycles, , vol. 72, p. 187 - 190
反应条件
T=100°C; Hilbert-Johnson reaction; P=6000600 Torr; 72 h;
参考文献
Heterocycles, , vol. 72, p. 187 - 190
反应条件
palladium diacetate; sodium nitrite in acetic acid 7 h; Heating;
参考文献
Bulletin of the Chemical Society of Japan, , vol. 56, # 7 p. 2171 - 2172
反应条件
potassium hydroxide; water und anschliessenden Erhitzen mit Dimethylsulfat;
参考文献
Justus Liebigs Annalen der Chemie, , vol. 484, p. 52,62
反应条件
potassium hydroxide; water und Erwaermen des Reaktionsprodukts in Aethanol mit Methyljodid;
参考文献
Justus Liebigs Annalen der Chemie, , vol. 484, p. 52,62
