1-乙基-3(3-二甲基氨基)脲合成路线 （共 8 条）
反应条件
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride With sodium carbonate in water; toluene 0.0833333 h; 2: N-hydroxy-2-(4-nitrophenyl)acetimidamide With oxygen in toluene 4 h; RefluxAir atmosphere;
参考文献
Ispikoudi, Maria; Amvrazis, Michalis; Kontogiorgis, Christos; Koumbis, Alexandros E.; Litinas, Konstantinos E.; Hadjipavlou-Litina, Dimitra; Fylaktakidou, Konstantina C.
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 12 p. 5635 - 5645
反应条件
in diethyl ether 2 h; Ambient temperature; Yield given;
参考文献
Williams,A.; Ibrahim,I.T.
Journal of the American Chemical Society, 1981 , vol. 103, p. 7090
反应条件
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride With sodium carbonate in water; toluene 0.0833333 h; 2: p-toluamidoxime With oxygen in toluene 4 h; RefluxAir atmosphere;
参考文献
Ispikoudi, Maria; Amvrazis, Michalis; Kontogiorgis, Christos; Koumbis, Alexandros E.; Litinas, Konstantinos E.; Hadjipavlou-Litina, Dimitra; Fylaktakidou, Konstantina C.
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 12 p. 5635 - 5645
反应条件
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride With sodium carbonate in water; toluene 0.0833333 h; 2: N'-hydroxy-4-methoxybenzimidamide With oxygen in toluene 4 h; RefluxAir atmosphere;
参考文献
Ispikoudi, Maria; Amvrazis, Michalis; Kontogiorgis, Christos; Koumbis, Alexandros E.; Litinas, Konstantinos E.; Hadjipavlou-Litina, Dimitra; Fylaktakidou, Konstantina C.
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 12 p. 5635 - 5645
反应条件
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride With sodium carbonate in water; toluene 0.0833333 h; 2: benzamidoxime With oxygen in toluene 4 h; RefluxAir atmosphere;
参考文献
Ispikoudi, Maria; Amvrazis, Michalis; Kontogiorgis, Christos; Koumbis, Alexandros E.; Litinas, Konstantinos E.; Hadjipavlou-Litina, Dimitra; Fylaktakidou, Konstantina C.
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 12 p. 5635 - 5645
反应条件
1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride With sodium carbonate in water; toluene 0.0833333 h; 2: 2-(4-chlorophenyl)-N'-hydroxyacetimidamide With oxygen in toluene 4 h; RefluxAir atmosphere;
参考文献
Ispikoudi, Maria; Amvrazis, Michalis; Kontogiorgis, Christos; Koumbis, Alexandros E.; Litinas, Konstantinos E.; Hadjipavlou-Litina, Dimitra; Fylaktakidou, Konstantina C.
European Journal of Medicinal Chemistry, 2010 , vol. 45, # 12 p. 5635 - 5645
反应条件
in dichloromethane; N,N-dimethyl-formamide T=20°C; Product distribution / selectivity;
参考文献
ROCHE DIAGNOSTICS GMBH; F. HOFFMANN-LA ROCHE AG
Patent: WO2009/49884 A1, 2009 ;
Location in patent: Page/Page column 21 ;
反应条件
triethylamine; p-toluenesulfonyl chloride in dichloromethane 4 h; Heating;
参考文献
Journal of the American Chemical Society, , vol. 103, p. 7090
