3-(三氟甲基)异氰酸苯酯合成路线 （共 25 条）
参考文献
Zeneca Limited
Patent: US5856273 A1, 1999 ;
参考文献
Curtis, Inc.
Patent: US6545005 B1, 2003 ;
反应条件
in hexane Ambient temperature;
参考文献
Chimishkyan, A. L.; Svetlova, L. P.; Leonova, T. V.; Gluyaev, N. D.
J. Gen. Chem. USSR (Engl. Transl.), 1984 , vol. 54, # 7 p. 1477 - 1481,1317 - 1320
反应条件
in tetrahydrofuran
2 h; Heating;
参考文献
Cegan; Vecere
Collection of Czechoslovak Chemical Communications, 1983 , vol. 48, # 5 p. 1440 - 1446
反应条件
in hexane
Ambient temperature;
参考文献
DeVries, Vern G.; Bloom, Jonathan D.; Dutia, Minu D.; Katocs, Andrew S.; Largis, Elwood E.
Journal of Medicinal Chemistry, 1989 , vol. 32, # 10 p. 2318 - 2325
反应条件
1: aqueous KOH / 24 h / Ambient temperature
2: 15percent HCl / 1 h / Heating
View Scheme
参考文献
Espada; Pedregal; Alonso; Lopez; Salazar; Martinez; Guillen
Farmaco (Societa chimica italiana : 1989), 1990 , vol. 45, # 11 p. 1237 - 1243
反应条件
N-benzyl-trimethylammonium hydroxide in diethyl ether
参考文献
Hanefeld
Archiv der Pharmazie, 1981 , vol. 314, # 4 p. 315 - 328
反应条件
1.) 100 deg C, 15 min; 2.) methanol, 1 h;
参考文献
Auzou; Desiles; Rips
European Journal of Medicinal Chemistry, 1981 , vol. 16, # 4 p. 345 - 348
反应条件
1: benzene / 20-25 deg C, 2 h; reflux, 2 h
2: KOH / H2O / 2 h
3: 80 percent / anhydrous Na2SO4, N2O4 / CH2Cl2 / 0 °C
View Scheme
参考文献
Adam,W.; Carballeira,N.
Journal of the American Chemical Society, 1984 , vol. 106, p. 2874
反应条件
1: 81 percent / diethyl ether / 1 h / Heating; room temp., 15 min.
2: 75 percent / 18percent hydrochloric acid / H2O / 1.5 h
3: 1.) ethyl chloroformate, triethylamine / 1.) benzene, ether, 0 deg C, 15 min; 2.) benzene, ether, room temp. 20 min
View Scheme
参考文献
Fontanella; Corsico; Diena; Occelli
Farmaco, Edizione Scientifica, 1984 , vol. 39, # 2 p. 133 - 153
