反应条件
1.1: caesium carbonate / N,N-dimethyl-formamide / 2 h / 40 °C
2.1: palladium on carbon; platinum(IV) oxide; hydrogen / methanol; ethyl acetate / 12 h
3.1: lithium hydroxide hydrate / tetrahydrofuran; water / 37 h / 0 - 20 °C
3.2: pH 4
4.1: N,N-dimethyl-formamide / 29 h / -20 - 20 °C
5.1: 4-(N,N-dimethlyamino)pyridine / N,N-dimethyl-formamide / 13 h / 0 - 20 °C
View Scheme
参考文献
Xiao, Jingbo; Free, R. Benjamin; Barnaeva, Elena; Conroy, Jennie L.; Doyle, Trevor; Miller, Brittney; Bryant-Genevier, Marthe; Taylor, Mercedes K.; Hu, Xin; Dulcey, Andres E.; Southall, Noel; Ferrer, Marc; Titus, Steve; Zheng, Wei; Sibley, David R.; Marugan, Juan J.
Journal of Medicinal Chemistry, 2014 , vol. 57, # 8 p. 3450 - 3463