(R)-1-Cbz-3-氰基吡咯烷合成路线 （共 6 条）
反应条件
in dimethyl sulfoxide T=80°C; 4 h;
参考文献
Klein, Scott I.; Czekaj, Mark; Molino, Bruce F.; Valeria, Chu
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 13 p. 1773 - 1778
反应条件
ethylenediaminetetraacetic acid in phosphate buffer T=30°C; pH=8.00; 18 h; Title compound not separated from byproducts.;
参考文献
Advanced Synthesis and Catalysis, , vol. 349, # 8-9 p. 1475 - 1480
反应条件
1: 1.41 g / Et3N; DMAP / CH2Cl2 / 3 h / 0 °C 2: 72 percent / dimethylsulfoxide / 4 h / 90 °C View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 1, # 9 p. 1498 - 1502
反应条件
1: Et3N / CH2Cl2 / 2 h / 0 °C 2: 1.41 g / Et3N; DMAP / CH2Cl2 / 3 h / 0 °C 3: 72 percent / dimethylsulfoxide / 4 h / 90 °C View Scheme
参考文献
Organic and Biomolecular Chemistry, , vol. 1, # 9 p. 1498 - 1502
反应条件
1: 60 percent / Ph3P; DEAD / benzene / 2 h / 20 °C 2: 70 percent / dimethylsulfoxide / 4 h / 80 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 10, # 24 p. 2755 - 2758
反应条件
hydrogenchloride in methanol; water 72 h; Ambient temperature;
参考文献
Klein, Scott I.; Czekaj, Mark; Molino, Bruce F.; Valeria, Chu
Bioorganic and Medicinal Chemistry Letters, 1997 , vol. 7, # 13 p. 1773 - 1778
