反应条件
1: 94 percent / Na, EtOH, H2O / 12 h
2: 67 percent / Na2S*9H2O / methanol / 4 h / Ambient temperature
3: 1.) diethyl cyanophosphonate, 2.) triethylamine / 1.) DMF, -20 deg C, 10 min, 2.) a) -20 deg C, 30 min, b) ambient temperature, 4 h
View Scheme
参考文献
Sivaramakrishnan, Santhosh; Breydo, Leonid; Sun, Daekyu; Gates, Kent S.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 11 p. 3791 - 3794
