2-甲基-4-三甲基硅乙炔基噻唑合成路线 （共 4 条）
反应条件
triethylamine; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide T=20°C; 72 h; Inert atmosphere;
参考文献
BRISTOL-MYERS SQUIBB COMPANY; DEGNAN, Andrew P.; HUANG, Hong; SNYDER, Lawrence B.; YANG, Fukang; GILLMAN, Kevin W.; PARKER, Michael F.
Patent: WO2012/64603 A1, 2012 ;
Location in patent: Page/Page column 63 ;
WO 2012/064603 A1
反应条件
in N,N-dimethyl-formamide T=20°C; 16 h;
参考文献
Cosford, Nicholas D. P.; Tehrani, Lida; Roppe, Jeffrey; Schweiger, Edwin; Smith, Nicholas D.; Anderson, Jeffrey; Bristow, Linda; Brodkin, Jesse; Jiang, Xiaohui; McDonald, Ian; Rao, Sara; Washburn, Mark; Varney, Mark A.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 2 p. 204 - 206
反应条件
1: AlCl3 / CH2Cl2 / 0 - 25 °C 2: 9.40 g / dimethylformamide / 17 h / 25 °C View Scheme
参考文献
Cosford, Nicholas D. P.; Tehrani, Lida; Roppe, Jeffrey; Schweiger, Edwin; Smith, Nicholas D.; Anderson, Jeffrey; Bristow, Linda; Brodkin, Jesse; Jiang, Xiaohui; McDonald, Ian; Rao, Sara; Washburn, Mark; Varney, Mark A.
Journal of Medicinal Chemistry, 2003 , vol. 46, # 2 p. 204 - 206
反应条件
tetrabutyl ammonium fluoride in tetrahydrofuran T=20°C; 0.166667 h;
参考文献
Recordati Ireland Limited
Patent: US2009/42841 A1, 2009 ;
Location in patent: Page/Page column 38 ;
US 20090042841 A1
