(3-溴-4-氯苯基)甲醇合成路线 (共 6 条)
反应条件
borane-THF in tetrahydrofuran T=0 - 20°C; Inert atmosphere;
参考文献
SANOFI; CHOI-SLEDESKI, Yong Mi; LIANG, Guyan; NIEDUZAK, Thaddeus R.; POLI, Gregory B.; SHUM, Patrick Wai-Kwok; STOKLOSA, Gregory T.; ZHAO, Zhicheng
Patent: WO2011/79102 A1, 2011 ;
Location in patent: Page/Page column 132 ;
WO 2011/079102 A1
反应条件
in methanol; water; toluene
参考文献
Maxia Pharmaceuticals, Inc.
Patent: US6515003 B1, 2003 ;
反应条件
lithium aluminium tetrahydride in diethyl ether T=20°C; Reduction; 0.5 h;
参考文献
Vu, Chi B.; Corpuz, Evelyn G.; Merry, Taylor J.; Pradeepan, Selvaluxmi G.; Bartlett, Catherine; Bohacek, Regine S.; Botfield, Martyn C.; Eyermann, Charles J.; Lynch, Berkley A.; MacNeil, Ian A.; Ram, Mary K.; Van Schravendijk, Marie Rose; Violette, Shelia; Sawyer, Tomi K.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 20 p. 4088 - 4098
反应条件
1: NBS; H2SO4 / 15 h / 20 °C 2: LiAlH4 / diethyl ether / 0.5 h / 20 °C View Scheme
参考文献
Vu, Chi B.; Corpuz, Evelyn G.; Merry, Taylor J.; Pradeepan, Selvaluxmi G.; Bartlett, Catherine; Bohacek, Regine S.; Botfield, Martyn C.; Eyermann, Charles J.; Lynch, Berkley A.; MacNeil, Ian A.; Ram, Mary K.; Van Schravendijk, Marie Rose; Violette, Shelia; Sawyer, Tomi K.
Journal of Medicinal Chemistry, 1999 , vol. 42, # 20 p. 4088 - 4098
反应条件
pyridinium chlorochromate in hexane; dichloromethane; ethyl acetate
参考文献
Maxia Pharmaceuticals, Inc.
Patent: US6515003 B1, 2003 ;
反应条件
phosphorus tribromide in dichloromethane
T=-5°C; 1 h;
参考文献
BAYER PHARMA AKTIENGESELLSCHAFT
Patent: US2012/172448 A1, 2012 ;
Location in patent: Page/Page column 25 ;