N-Boc-N'-三苯甲基-L-组氨酸合成路线 （共 17 条）
反应条件
lithium hydroxide in methanol T=4°C; 2 h;
参考文献
Boger, Dale L.; Teramoto, Shuji; Cai, Hui
Bioorganic and Medicinal Chemistry, 1996 , vol. 4, # 2 p. 179 - 193
反应条件
potassium carbonate in isopropyl alcohol T=30 - 35°C; 0.666667 h;
参考文献
Pozdnev, V. F.
Chemistry of Natural Compounds, 1982 , vol. 18, # 3 p. 322 - 327
Khimiya Prirodnykh Soedinenii, 1982 , # 3 p. 349 - 354
反应条件
1: 99 percent / Et3N / benzene / 1 h / 80 °C 2: 0.78 g / H2 / 10percent Pd/C / methanol / 2.5 h / 25 °C / 760 Torr 3: 98 percent / aq. NaHCO3 / tetrahydrofuran / 2 h / 25 °C 4: 85 percent / 0.1 N aq. LiOH / methanol / 2 h / 4 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 4, # 2 p. 179 - 193
反应条件
1: 80 percent / 1N aq. NaOH / methanol / 0.01 h / -20 °C 2: 99 percent / Et3N / benzene / 1 h / 80 °C 3: 0.78 g / H2 / 10percent Pd/C / methanol / 2.5 h / 25 °C / 760 Torr 4: 98 percent / aq. NaHCO3 / tetrahydrofuran / 2 h / 25 °C 5: 85 percent / 0.1 N aq. LiOH / methanol / 2 h / 4 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 4, # 2 p. 179 - 193
反应条件
1: 99 percent / SOCl2 / 36 h / 40 °C 2: 49 percent / aq. NaHCO3 / acetone / 12 h / 25 °C 3: 80 percent / 1N aq. NaOH / methanol / 0.01 h / -20 °C 4: 99 percent / Et3N / benzene / 1 h / 80 °C 5: 0.78 g / H2 / 10percent Pd/C / methanol / 2.5 h / 25 °C / 760 Torr 6: 98 percent / aq. NaHCO3 / tetrahydrofuran / 2 h / 25 °C 7: 85 percent / 0.1 N aq. LiOH / methanol / 2 h / 4 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 4, # 2 p. 179 - 193
反应条件
1: 49 percent / aq. NaHCO3 / acetone / 12 h / 25 °C 2: 80 percent / 1N aq. NaOH / methanol / 0.01 h / -20 °C 3: 99 percent / Et3N / benzene / 1 h / 80 °C 4: 0.78 g / H2 / 10percent Pd/C / methanol / 2.5 h / 25 °C / 760 Torr 5: 98 percent / aq. NaHCO3 / tetrahydrofuran / 2 h / 25 °C 6: 85 percent / 0.1 N aq. LiOH / methanol / 2 h / 4 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 4, # 2 p. 179 - 193
反应条件
1: 69 percent / SOCl2 / 15 h / 25 °C 2: 99 percent / Et3N / benzene / 1 h / 80 °C 3: 0.78 g / H2 / 10percent Pd/C / methanol / 2.5 h / 25 °C / 760 Torr 4: 98 percent / aq. NaHCO3 / tetrahydrofuran / 2 h / 25 °C 5: 85 percent / 0.1 N aq. LiOH / methanol / 2 h / 4 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 4, # 2 p. 179 - 193
反应条件
1: 99 percent / Et3N / benzene / 1 h / 80 °C 2: 0.78 g / H2 / 10percent Pd/C / methanol / 2.5 h / 25 °C / 760 Torr 3: 98 percent / aq. NaHCO3 / tetrahydrofuran / 2 h / 25 °C 4: 85 percent / 0.1 N aq. LiOH / methanol / 2 h / 4 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 4, # 2 p. 179 - 193
反应条件
1: 0.78 g / H2 / 10percent Pd/C / methanol / 2.5 h / 25 °C / 760 Torr 2: 98 percent / aq. NaHCO3 / tetrahydrofuran / 2 h / 25 °C 3: 85 percent / 0.1 N aq. LiOH / methanol / 2 h / 4 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 4, # 2 p. 179 - 193
反应条件
1: 98 percent / aq. NaHCO3 / tetrahydrofuran / 2 h / 25 °C 2: 85 percent / 0.1 N aq. LiOH / methanol / 2 h / 4 °C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 4, # 2 p. 179 - 193
