1-乙酰基环丙烷羧酸乙酯合成路线 （共 19 条）
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , p. 65 - 68
参考文献
Journal of the Chemical Society, vol. 59, p. 855,878
Journal of the Chemical Society, vol. 57, p. 215
Journal of the Chemical Society, vol. 51, p. 822
Chemische Berichte, vol. 19, p. 2045
Journal of the Chemical Society, vol. 47, p. 829
参考文献
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, , vol. 145, p. 61
Hoppe-Seyler's Zeitschrift fuer Physiologische Chemie, , vol. 172, p. 234
反应条件
hydrogen bromide 48 h; Yield given;
参考文献
Townsend, Craig A.; Christensen, Siegfried B.; Davis, Steven G.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), 1988 , p. 839 - 862
反应条件
potassium hydroxide in ethanol T=0°C; 24 h;
参考文献
Padwa, Albert; Chinn, Richard L.; Hornbuckle, Susan F.; Zhang, Zhijia J.
Journal of Organic Chemistry, 1991 , vol. 56, # 10 p. 3271 - 3278
反应条件
1: ethyl 1-acetyl-1-cyclopropanecarboxylate With bromine in ethanol 2 h; 2: benzylamine in ethanol T=0 - 20°C; Product distribution / selectivity;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2009/61879 A1, 2009 ;
Location in patent: Page/Page column 166, 178 ;
反应条件
bromine in ethanol T=30°C; 1.33333 h;
参考文献
Heterocycles, , vol. 63, # 3 p. 699 - 706
参考文献
v. Rothenburg
Journal fuer Praktische Chemie (Leipzig), 1895 , vol. <2> 51, p. 61
反应条件
1: 1.) NaNH2 / 1.) ether, 24 h, reflux, 2.) ether, 30 min, reflux
2: 29 percent Chromat. / H2 / Pd(5percent)/C / diethyl ether / Ambient temperature
View Scheme
参考文献
Kirmse, Wolfgang; Rode, Jutta; Rode, Klaus
Chemische Berichte, 1986 , vol. 119, # 12 p. 3672 - 3693
