N-苯甲酰基-(2R,3S)-3-苯基异丝氨酸甲酯合成路线 （共 130 条）
反应条件
1: 1.) DBU, 2.) IBr, K2CO3 / 1.) CH3CN, -30 deg C, 2.) CH3CN, -30 to -10 deg C 2: 6N HCl / methanol / Ambient temperature 3: NaHCO3 / methanol / 0 °C 4: 1.) NaIO4, 2.) NaClO2, NaH2PO4 / 1.) acetone, H2O, RT, 2.) 2-methyl-2-butene, t-BuOH, H2O, RT 5: methanol / 0 °C 6: H2O, AcCl / methanol / Heating 7: NaHCO3 / H2O / Ambient temperature View Scheme
参考文献
Tetrahedron Letters, , vol. 40, # 18 p. 3581 - 3582
反应条件
1: H2O, AcCl / methanol / Heating 2: NaHCO3 / H2O / Ambient temperature View Scheme
参考文献
Tetrahedron Letters, , vol. 40, # 18 p. 3581 - 3582
反应条件
1: 1.) NaIO4, 2.) NaClO2, NaH2PO4 / 1.) acetone, H2O, RT, 2.) 2-methyl-2-butene, t-BuOH, H2O, RT 2: methanol / 0 °C 3: H2O, AcCl / methanol / Heating 4: NaHCO3 / H2O / Ambient temperature View Scheme
参考文献
Tetrahedron Letters, , vol. 40, # 18 p. 3581 - 3582
反应条件
1: 6N HCl / methanol / Ambient temperature 2: NaHCO3 / methanol / 0 °C 3: 1.) NaIO4, 2.) NaClO2, NaH2PO4 / 1.) acetone, H2O, RT, 2.) 2-methyl-2-butene, t-BuOH, H2O, RT 4: methanol / 0 °C 5: H2O, AcCl / methanol / Heating 6: NaHCO3 / H2O / Ambient temperature View Scheme
参考文献
Tetrahedron Letters, , vol. 40, # 18 p. 3581 - 3582
反应条件
1: 62 percent / pyridine 2: 70 percent / K2CO3 / methanol; H2O 3: KF / H2O View Scheme
参考文献
Tetrahedron Letters, , vol. 35, # 18 p. 2845 - 2848
反应条件
1: 70 percent / K2CO3 / methanol; H2O 2: KF / H2O View Scheme
参考文献
Tetrahedron Letters, , vol. 35, # 18 p. 2845 - 2848
反应条件
1: 81 percent / pyridine / CH2Cl2 / Ambient temperature 2: 71 percent / LiI / methanol / Ambient temperature; 2 weeks View Scheme
参考文献
Tetrahedron, , vol. 49, # 14 p. 2805 - 2828
反应条件
sodium hydroxide; hydrogen; palladium on activated charcoal 1.) MeOH, room temp., 30 h, 2.) THF, water, 0 deg C, 30 min; Yield given. Multistep reaction;
参考文献
Tetrahedron, , vol. 50, # 9 p. 2785 - 2792
反应条件
1: 1.) HN3, Ph3P, DEAD; 2.) PPh3, H2O / 1.) benzene, r.t.; 2.) THF, 55 deg C 2: 90 percent / DMAP / CH2Cl2 / 0 °C 3: 96 percent / SnCl4 / CH2Cl2 / Heating 4: 84 percent / AgOCOCF3 / Ambient temperature View Scheme
参考文献
Chemistry Letters, , # 1 p. 3 - 4
反应条件
1: 90 percent / DMAP / CH2Cl2 / 0 °C 2: 96 percent / SnCl4 / CH2Cl2 / Heating 3: 84 percent / AgOCOCF3 / Ambient temperature View Scheme
参考文献
Chemistry Letters, , # 1 p. 3 - 4
