N-苯甲酰基-(2R,3S)-3-苯基异丝氨酸甲酯合成路线 （共 130 条）
反应条件
1: 96 percent / SnCl4 / CH2Cl2 / Heating 2: 84 percent / AgOCOCF3 / Ambient temperature View Scheme
参考文献
Chemistry Letters, , # 1 p. 3 - 4
反应条件
1.1: tetrahydrofuran / 3 h / -4 - 25 °C 2.1: sodium hydride / tetrahydrofuran; mineral oil / 3 h / -15 °C / |Inert atmosphere 2.2: -15 - 20 °C / |Inert atmosphere 3.1: caesium carbonate / tetrahydrofuran / 1.5 h / 20 °C View Scheme
参考文献
Russian Chemical Bulletin, , vol. 61, # 11 p. 2149 - 2162
Izv. Akad. Nauk, Ser. Khim., , # 11 p. 2132 - 2145,14
反应条件
(+)-(2S,8aS)-(camphorylsulfonyl)oxaziridine; lithium chloride; lithium diisopropyl amide 1) -42 deg C, 2) -100 to -78 deg C; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Journal of Organic Chemistry, , vol. 57, # 24 p. 6387 - 6389
反应条件
2: aq. LiOH, 30percent aq. H2O2 / tetrahydrofuran / 15 h / 0 °C 3: diethyl ether; methanol View Scheme
参考文献
Angewandte Chemie, , vol. 108, # 15 p. 1809 - 1812
反应条件
1: aq. LiOH, 30percent aq. H2O2 / tetrahydrofuran / 15 h / 0 °C 2: diethyl ether; methanol View Scheme
参考文献
Angewandte Chemie, , vol. 108, # 15 p. 1809 - 1812
反应条件
2: 75 percent / NaHCO3 / CH2Cl2; H2O 3: 1.)KHMDS; 2.) MoOPH / 1.) toluene, THF, -78 deg C to -25 deg C; 2.) toluene, THF, -60 deg C, 3 h View Scheme
参考文献
Canadian Journal of Chemistry, , vol. 74, # 4 p. 621 - 624
反应条件
1: 75 percent / NaHCO3 / CH2Cl2; H2O 2: 1.)KHMDS; 2.) MoOPH / 1.) toluene, THF, -78 deg C to -25 deg C; 2.) toluene, THF, -60 deg C, 3 h View Scheme
参考文献
Canadian Journal of Chemistry, , vol. 74, # 4 p. 621 - 624
反应条件
1: 1) LDA / 2) -78 deg C 2: 1) CF3CO2H, 2) Et3N, DMAP / 1) MeOH 3: 1) LDA, LiCl, 2) (+)-(camphorsulfonyl)oxaziridine / 1) -42 deg C, 2) -100 to -78 deg C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 57, # 24 p. 6387 - 6389
反应条件
in methanol Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 58, # 22 p. 5889 - 5891
反应条件
in methanol Title compound not separated from byproducts;
参考文献
Journal of Organic Chemistry, , vol. 58, # 22 p. 5889 - 5891
