N-苯甲酰基-(2R,3S)-3-苯基异丝氨酸甲酯合成路线 （共 130 条）
反应条件
1: 1.) Et3N / 1) CH2Cl2, 20 min, room temperature; 2) CH2Cl2, room temperature, overnight 2: 77 percent / Ph3P, diethylazodicarboxylate / tetrahydrofuran / Ambient temperature 3: 1.) aq. HCl, 2.) aq. NaHCO3 / 1) CH3OH, room temperature, 1.5 h; 2) room temperature, 16 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 17 p. 2385 - 2392
反应条件
1: DMAP / CH2Cl2 / 1 h / Ambient temperature 2: 100 percent / thallium trinitrate trihydrate / 27 °C 3: 78 percent / H2, 10percent HCl / 10percent Pd/C / ethanol / 1 h / 60 °C View Scheme
参考文献
Tetrahedron, , vol. 49, # 37 p. 8323 - 8336
反应条件
1: 72 mg / triphenylphosphine, water / tetrahydrofuran / 15 h / 60 °C 2: DMAP / CH2Cl2 / 1 h / Ambient temperature 3: 100 percent / thallium trinitrate trihydrate / 27 °C 4: 78 percent / H2, 10percent HCl / 10percent Pd/C / ethanol / 1 h / 60 °C View Scheme
参考文献
Tetrahedron, , vol. 49, # 37 p. 8323 - 8336
反应条件
1: 100 percent / thallium trinitrate trihydrate / 27 °C 2: 78 percent / H2, 10percent HCl / 10percent Pd/C / ethanol / 1 h / 60 °C View Scheme
参考文献
Tetrahedron, , vol. 49, # 37 p. 8323 - 8336
反应条件
1: 91 percent / DMAP / CH2Cl2 / 1 h / 23 °C 2: 93 percent / H2 / 10percent Pd-C / methanol / 4 h / 23 °C / 2585.7 Torr 3: aq. Na2CO3 / methanol / 4 h / 23 °C 4: ethyl acetate 5: 1) SOCl2 / 1) CHCl3, 45 deg C, 5 h, 2) CHCl3, reflux, 48 h 6: 80 percent / 1N HCl / methanol / 2 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 58, # 5 p. 1287 - 1289
反应条件
1: 93 percent / H2 / 10percent Pd-C / methanol / 4 h / 23 °C / 2585.7 Torr 2: aq. Na2CO3 / methanol / 4 h / 23 °C 3: ethyl acetate 4: 1) SOCl2 / 1) CHCl3, 45 deg C, 5 h, 2) CHCl3, reflux, 48 h 5: 80 percent / 1N HCl / methanol / 2 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 58, # 5 p. 1287 - 1289
反应条件
1: 1.) sodium bicarbonate, sodium periodate, ruthenium trichloride trihydrate / 1.) CCl4, acetonitrile, water, 20 deg C, 44 h, 2.) Et2O 2: 90 percent / azidotrimethylsilane, zinc chloride / 48 h / 68 °C 3: 94 percent / triethylamine, 4-(dimethylamino)pyridine / CH2Cl2 / 1 h 4: 1.) H2 / 1.) 10percent Pd/C / 1.) CH3OH, 15 h, 2.) CH3OH, RT, 72 h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 51, # 1 p. 46 - 50
反应条件
1: 88 percent / triethylamine / CH2Cl2 / 63 h / 0 °C 2: 91 percent / K2CO3 / dimethylformamide; H2O / 24 h / 20 °C 3: 95 percent / NaN3 / methanol; H2O; methyl formate / 46 h / 50 °C 4: 1.) triethylamine, 4-(dimethylamino)pyridine, 2.) H2 / 2.) Pd-C / 1a.) ethyl acetate, 20 deg C, 4h, 1b.) MeOH, 3h, 2.) 68h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 55, # 6 p. 1957 - 1959
反应条件
1: 91 percent / K2CO3 / dimethylformamide; H2O / 24 h / 20 °C 2: 95 percent / NaN3 / methanol; H2O; methyl formate / 46 h / 50 °C 3: 1.) triethylamine, 4-(dimethylamino)pyridine, 2.) H2 / 2.) Pd-C / 1a.) ethyl acetate, 20 deg C, 4h, 1b.) MeOH, 3h, 2.) 68h View Scheme
参考文献
Journal of Organic Chemistry, , vol. 55, # 6 p. 1957 - 1959
反应条件
1: 96 percent / NaN3; NH4Cl / H2O; acetone / 23 h / Heating 2: DMAP / CH2Cl2 / 4 h / 20 °C 3: H2 / 10 percent Pd/C / methanol / 48 h / 20 °C / 760 Torr 4: 90 percent / DEAD; PPh3 / benzene / 20 h / 20 °C 5: 90 percent / 1N aq. HCl / methanol / 2 h / Heating View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 11, # 22 p. 4485 - 4497
