N-苯甲酰基-(2R,3S)-3-苯基异丝氨酸甲酯合成路线 （共 130 条）
反应条件
1: 90 percent / conc. aq. HCl / acetone; methanol / 23 h / 20 °C 2: 83 percent / NaN3 / dimethylformamide / 48 h / 60 °C 3: DMAP / CH2Cl2 / 4 h / 20 °C 4: H2 / 10 percent Pd/C / methanol / 48 h / 20 °C / 760 Torr 5: 90 percent / DEAD; PPh3 / benzene / 20 h / 20 °C 6: 90 percent / 1N aq. HCl / methanol / 2 h / Heating View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 11, # 22 p. 4485 - 4497
反应条件
1: DMAP / CH2Cl2 / 4 h / 20 °C 2: H2 / 10 percent Pd/C / methanol / 48 h / 20 °C / 760 Torr 3: 90 percent / DEAD; PPh3 / benzene / 20 h / 20 °C 4: 90 percent / 1N aq. HCl / methanol / 2 h / Heating View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 11, # 22 p. 4485 - 4497
反应条件
1: 83 percent / NaN3 / dimethylformamide / 48 h / 60 °C 2: DMAP / CH2Cl2 / 4 h / 20 °C 3: H2 / 10 percent Pd/C / methanol / 48 h / 20 °C / 760 Torr 4: 90 percent / DEAD; PPh3 / benzene / 20 h / 20 °C 5: 90 percent / 1N aq. HCl / methanol / 2 h / Heating View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 11, # 22 p. 4485 - 4497
反应条件
1: 93 percent / K2CO3 / methanol / 2 h / -20 - 0 °C 2: 96 percent / NaN3; NH4Cl / H2O; acetone / 23 h / Heating 3: DMAP / CH2Cl2 / 4 h / 20 °C 4: H2 / 10 percent Pd/C / methanol / 48 h / 20 °C / 760 Torr 5: 90 percent / DEAD; PPh3 / benzene / 20 h / 20 °C 6: 90 percent / 1N aq. HCl / methanol / 2 h / Heating View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 11, # 22 p. 4485 - 4497
反应条件
1: 82 percent / NaN3 / dimethylformamide / 40 h / 60 °C 2: 100 percent / DMAP / CH2Cl2 / 6 h / 20 °C 3: 71 percent / H2 / 10 percent Pd/C / methanol / 48 h / 20 °C / 760 Torr View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 11, # 22 p. 4485 - 4497
反应条件
1: 27 percent / NaOMe / methanol / 10 h / 0 °C 2: 75 percent / NaN3; NH4Cl / H2O; acetone / 24 h / Heating 3: 100 percent / DMAP / CH2Cl2 / 6 h / 20 °C 4: 71 percent / H2 / 10 percent Pd/C / methanol / 48 h / 20 °C / 760 Torr View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 11, # 22 p. 4485 - 4497
反应条件
1: 83 percent / 1.) p-TsOH; 2.) K2CO3 / methanol 2: 94 percent / NaN3 / dimethylformamide 3: 1.) Et3N; 2.) H2 / 2.) Pd/C View Scheme
参考文献
Tetrahedron Letters, , vol. 39, # 15 p. 2163 - 2166
反应条件
1: triphenyphosphine, hydrazoic acid, diethyl azodicarboxylate / benzene / 1 h / Ambient temperature 2: triphenylphosphine, water / tetrahydrofuran / 15 h / 60 °C 3: DMAP / CH2Cl2 / 1 h / Ambient temperature 4: 78 percent / H2, 10percent HCl / 10percent Pd/C / ethanol / 1 h / 60 °C View Scheme
参考文献
Tetrahedron, , vol. 49, # 37 p. 8323 - 8336
反应条件
lithium iodide in methanol Ambient temperature2 weeks;
参考文献
Tetrahedron, , vol. 49, # 14 p. 2805 - 2828
反应条件
1.1: 66 percent / 120 °C / 0.5 Torr 2.1: NaHMDS / tetrahydrofuran / -78 - 20 °C 2.2: SiO2 3.1: 82 percent / aq. HCl / dioxane / 0.67 h / 50 °C 4.1: 95 percent / pyridine; DMAP / CH2Cl2 / 1 h / 20 °C 5.1: NaIO4; RuCl3 / acetonitrile; CCl4; H2O / 6 h 6.1: 36 mg / diethyl ether; methanol; hexane / 0.5 h / 20 °C 7.1: 92 percent / NaOMe / methanol / 1 h / 20 °C View Scheme
参考文献
Organic Letters, , vol. 5, # 21 p. 3987 - 3990
