N-苯甲酰基-(2R,3S)-3-苯基异丝氨酸甲酯合成路线 （共 130 条）
反应条件
1.1: 57 percent / toluene / 24 h / γ-Irradiation 2.1: 88 percent / methanol / 20 °C 3.1: 66 percent / 120 °C / 0.5 Torr 4.1: NaHMDS / tetrahydrofuran / -78 - 20 °C 4.2: SiO2 5.1: 82 percent / aq. HCl / dioxane / 0.67 h / 50 °C 6.1: 95 percent / pyridine; DMAP / CH2Cl2 / 1 h / 20 °C 7.1: NaIO4; RuCl3 / acetonitrile; CCl4; H2O / 6 h 8.1: 36 mg / diethyl ether; methanol; hexane / 0.5 h / 20 °C 9.1: 92 percent / NaOMe / methanol / 1 h / 20 °C View Scheme
参考文献
Organic Letters, , vol. 5, # 21 p. 3987 - 3990
反应条件
1.1: 88 percent / methanol / 20 °C 2.1: 66 percent / 120 °C / 0.5 Torr 3.1: NaHMDS / tetrahydrofuran / -78 - 20 °C 3.2: SiO2 4.1: 82 percent / aq. HCl / dioxane / 0.67 h / 50 °C 5.1: 95 percent / pyridine; DMAP / CH2Cl2 / 1 h / 20 °C 6.1: NaIO4; RuCl3 / acetonitrile; CCl4; H2O / 6 h 7.1: 36 mg / diethyl ether; methanol; hexane / 0.5 h / 20 °C 8.1: 92 percent / NaOMe / methanol / 1 h / 20 °C View Scheme
参考文献
Organic Letters, , vol. 5, # 21 p. 3987 - 3990
反应条件
1: Et3N / CH2Cl2 / 1 h 2: 81 percent / BF3*OEt2 / CH2Cl2 / 1 h / 20 °C 3: 82 percent / aq. HCl / dioxane / 0.67 h / 50 °C 4: 95 percent / pyridine; DMAP / CH2Cl2 / 1 h / 20 °C 5: NaIO4; RuCl3 / acetonitrile; CCl4; H2O / 6 h 6: 36 mg / diethyl ether; methanol; hexane / 0.5 h / 20 °C 7: 92 percent / NaOMe / methanol / 1 h / 20 °C View Scheme
参考文献
Organic Letters, , vol. 5, # 21 p. 3987 - 3990
反应条件
1: 82 percent / aq. HCl / dioxane / 0.67 h / 50 °C 2: 95 percent / pyridine; DMAP / CH2Cl2 / 1 h / 20 °C 3: NaIO4; RuCl3 / acetonitrile; CCl4; H2O / 6 h 4: 36 mg / diethyl ether; methanol; hexane / 0.5 h / 20 °C 5: 92 percent / NaOMe / methanol / 1 h / 20 °C View Scheme
参考文献
Organic Letters, , vol. 5, # 21 p. 3987 - 3990
反应条件
1: 81 percent / BF3*OEt2 / CH2Cl2 / 1 h / 20 °C 2: 82 percent / aq. HCl / dioxane / 0.67 h / 50 °C 3: 95 percent / pyridine; DMAP / CH2Cl2 / 1 h / 20 °C 4: NaIO4; RuCl3 / acetonitrile; CCl4; H2O / 6 h 5: 36 mg / diethyl ether; methanol; hexane / 0.5 h / 20 °C 6: 92 percent / NaOMe / methanol / 1 h / 20 °C View Scheme
参考文献
Organic Letters, , vol. 5, # 21 p. 3987 - 3990
反应条件
1: 95 percent / pyridine; DMAP / CH2Cl2 / 1 h / 20 °C 2: NaIO4; RuCl3 / acetonitrile; CCl4; H2O / 6 h 3: 36 mg / diethyl ether; methanol; hexane / 0.5 h / 20 °C 4: 92 percent / NaOMe / methanol / 1 h / 20 °C View Scheme
参考文献
Organic Letters, , vol. 5, # 21 p. 3987 - 3990
反应条件
1: 36 mg / diethyl ether; methanol; hexane / 0.5 h / 20 °C 2: 92 percent / NaOMe / methanol / 1 h / 20 °C View Scheme
参考文献
Organic Letters, , vol. 5, # 21 p. 3987 - 3990
反应条件
1: NaIO4; RuCl3 / acetonitrile; CCl4; H2O / 6 h 2: 36 mg / diethyl ether; methanol; hexane / 0.5 h / 20 °C 3: 92 percent / NaOMe / methanol / 1 h / 20 °C View Scheme
参考文献
Organic Letters, , vol. 5, # 21 p. 3987 - 3990
反应条件
1.1: AcCl / Heating 2.1: Et3N / CH2Cl2 / 20 °C 3.1: tetrahydrofuran / -78 °C 4.1: NaH / tetrahydrofuran / 20 °C 5.1: O3; NaOH / CH2Cl2 / -78 °C 6.1: HCl / methanol / 20 °C 7.1: 75 percent / Zn(BH4)2 / tetrahydrofuran / -78 °C 8.1: NaHCO3 / methanol / 0 °C 9.1: SOCl2 / CH2Cl2 / Heating 10.1: HCl / H2O; methanol / Heating 10.2: NaHCO3 / H2O; methanol / 50 °C View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 14, # 23 p. 3639 - 3641
反应条件
1: 1) NaIO4, RuCl3 / 1) MeCN, CCl4, H2O 2: 98 percent / MgBr2*Et2O / diethyl ether / 1) -60 deg C, 2 h, 2) -40 deg C, 4 h 3: 98 percent / NaN3 / acetone; H2O 4: 96 percent / DMAP, Et3N 5: 88 percent / H2 / Pd/C / methanol View Scheme
参考文献
Journal of the Chemical Society - Series Chemical Communications, , # 24 p. 2767 - 2768
