N-苯甲酰基-(2R,3S)-3-苯基异丝氨酸甲酯合成路线 （共 130 条）
反应条件
1: 87 percent / (+)-diisopropyl tartrate, Ti(OiPr)4, tBuOOH 2: 1) NaIO4, RuCl3 / 1) MeCN, CCl4, H2O 3: 98 percent / MgBr2*Et2O / diethyl ether / 1) -60 deg C, 2 h, 2) -40 deg C, 4 h 4: 98 percent / NaN3 / acetone; H2O 5: 96 percent / DMAP, Et3N 6: 88 percent / H2 / Pd/C / methanol View Scheme
参考文献
Journal of the Chemical Society - Series Chemical Communications, , # 24 p. 2767 - 2768
反应条件
1: H2 / Pd-C / 5320 Torr / Ambient temperature 2: HCl / Ambient temperature 3: 1.) Et3N / 1) CH2Cl2, 20 min, room temperature; 2) CH2Cl2, room temperature, overnight 4: 77 percent / Ph3P, diethylazodicarboxylate / tetrahydrofuran / Ambient temperature 5: 1.) aq. HCl, 2.) aq. NaHCO3 / 1) CH3OH, room temperature, 1.5 h; 2) room temperature, 16 h View Scheme
参考文献
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999), , # 17 p. 2385 - 2392
反应条件
caesium carbonate in tetrahydrofuran; methanol T=20°C;
参考文献
Russian Chemical Bulletin, , vol. 61, # 11 p. 2149 - 2162
Izv. Akad. Nauk, Ser. Khim., , # 11 p. 2132 - 2145,14
反应条件
1: HCl / methanol / 1 h 2: 0.123 g / NaHCO3 / H2O; tetrahydrofuran / 2 h / 0 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 71, # 4 p. 1588 - 1591
反应条件
1: 96 percent / LiHMDS / tetrahydrofuran / -78 °C 2: HCl / methanol / 1 h 3: 0.123 g / NaHCO3 / H2O; tetrahydrofuran / 2 h / 0 °C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 71, # 4 p. 1588 - 1591
反应条件
1: dimethylformamide; diethyl ether 2: 85 percent / HCl / methanol / 5 h / Heating View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 15, # 6 p. 941 - 949
反应条件
1: 75 percent / Et3N / acetone; H2O / 1.) -5 deg C, 2 h, 2.) room temp., 3 h 2: 3.75 mmol / penicillin G acylase/Eupergit / ethanol; H2O / 4 h / Ambient temperature 3: 0.75 g / Et3N / acetone / 1.) -5 deg C, 2 h, 2.) room temp., 3 h 4: SOCl2 / Ambient temperature 5: 1.) LiHMDS, 2.) I2 / 1.) THF, 0 deg C, 1 h, 2.) THF, 1 h 6: 85 percent / aq. HCl / methanol / 5 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 63, # 7 p. 2351 - 2353
反应条件
1: SOCl2 / Ambient temperature 2: 1.) LiHMDS, 2.) I2 / 1.) THF, 0 deg C, 1 h, 2.) THF, 1 h 3: 85 percent / aq. HCl / methanol / 5 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 63, # 7 p. 2351 - 2353
反应条件
1: 3.75 mmol / penicillin G acylase/Eupergit / ethanol; H2O / 4 h / Ambient temperature 2: 0.75 g / Et3N / acetone / 1.) -5 deg C, 2 h, 2.) room temp., 3 h 3: SOCl2 / Ambient temperature 4: 1.) LiHMDS, 2.) I2 / 1.) THF, 0 deg C, 1 h, 2.) THF, 1 h 5: 85 percent / aq. HCl / methanol / 5 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 63, # 7 p. 2351 - 2353
反应条件
1: 0.75 g / Et3N / acetone / 1.) -5 deg C, 2 h, 2.) room temp., 3 h 2: SOCl2 / Ambient temperature 3: 1.) LiHMDS, 2.) I2 / 1.) THF, 0 deg C, 1 h, 2.) THF, 1 h 4: 85 percent / aq. HCl / methanol / 5 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 63, # 7 p. 2351 - 2353
