N-苯甲酰基-(2R,3S)-3-苯基异丝氨酸甲酯合成路线 （共 130 条）
反应条件
1: 1.) LiHMDS, 2.) I2 / 1.) THF, 0 deg C, 1 h, 2.) THF, 1 h 2: 85 percent / aq. HCl / methanol / 5 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 63, # 7 p. 2351 - 2353
反应条件
1: (+)-N-(phenylsulfonyl)(3,3-dichlorocamphoryl)oxaziridine / CCl4 / 10 h / -20 - 20 °C 2: 1) LDA / 2) -78 deg C 3: 1) CF3CO2H, 2) Et3N, DMAP / 1) MeOH 4: 1) LDA, LiCl, 2) (+)-(camphorsulfonyl)oxaziridine / 1) -42 deg C, 2) -100 to -78 deg C View Scheme
参考文献
Journal of Organic Chemistry, , vol. 57, # 24 p. 6387 - 6389
反应条件
1: aq. Na2CO3 / methanol / 4 h / 23 °C 2: ethyl acetate 3: 1) SOCl2 / 1) CHCl3, 45 deg C, 5 h, 2) CHCl3, reflux, 48 h 4: 80 percent / 1N HCl / methanol / 2 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 58, # 5 p. 1287 - 1289
反应条件
1: ethyl acetate 2: 1) SOCl2 / 1) CHCl3, 45 deg C, 5 h, 2) CHCl3, reflux, 48 h 3: 80 percent / 1N HCl / methanol / 2 h / Heating View Scheme
参考文献
Journal of Organic Chemistry, , vol. 58, # 5 p. 1287 - 1289
反应条件
in methanol T=25°C; 1 h;
参考文献
Brieva, Rosario; Crich, Joyce Z.; Sih, Charles J.
Journal of Organic Chemistry, 1993 , vol. 58, # 5 p. 1068 - 1075
反应条件
1: 73 percent / HCl 2: NaBH4 3: 62 percent / pyridine 4: 70 percent / K2CO3 / methanol; H2O 5: KF / H2O View Scheme
参考文献
Tetrahedron Letters, , vol. 35, # 18 p. 2845 - 2848
反应条件
1: NaBH4 2: 62 percent / pyridine 3: 70 percent / K2CO3 / methanol; H2O 4: KF / H2O View Scheme
参考文献
Tetrahedron Letters, , vol. 35, # 18 p. 2845 - 2848
反应条件
potassium fluoride in water
参考文献
Tetrahedron Letters, , vol. 35, # 18 p. 2845 - 2848
反应条件
1: pyridinium chlorochromate / dimethylformamide / 2 h 2: dimethylformamide; diethyl ether 3: 85 percent / HCl / methanol / 5 h / Heating View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 15, # 6 p. 941 - 949
反应条件
1: 94 percent / tetrabutylammonium fluoride / tetrahydrofuran / 1 h 2: pyridinium chlorochromate / dimethylformamide / 2 h 3: dimethylformamide; diethyl ether 4: 85 percent / HCl / methanol / 5 h / Heating View Scheme
参考文献
Tetrahedron Asymmetry, , vol. 15, # 6 p. 941 - 949
