10-脱乙酰基巴卡丁 III合成路线 （共 66 条）
反应条件
1.1: copper(I) bromide; zinc dibromide / tetrahydrofuran / 21.5 h / 60 °C 2.1: pyridine / dichloromethane / 2.83 h / -30 - 0 °C 3.1: sodium azide / acetonitrile / Inert atmosphere; Reflux 4.1: sodium hydride / tetrahydrofuran; mineral oil / 1 h / -15 - 5 °C / Inert atmosphere 4.2: 1 h / -5 - 5 °C / Inert atmosphere 4.3: 1.5 h / Inert atmosphere 5.1: hydrogenchloride / water; methanol / 2.5 h / 0 - 5 °C View Scheme
参考文献
Kung, Liang-Rern; Chang, Shih-Sheng; Fang, Tung-Shen; Lin, Shu-Fen; Chang, Cheng-Chang; Chen, Chia-Hui; Hung, Yi-Ting; Cheng, Ming-Ching
Patent: US2012/149925 A1, 2012 ;
反应条件
1: pyridine / 0.5 h / 20 °C 2: dicyclohexyl-carbodiimide; 4-(N,N-dimethlyamino)pyridine / toluene 3: formic acid / 2 h / 20 °C View Scheme
参考文献
Chang, Jun; Hao, Xiao-Dong; Hao, Yun-Peng; Lu, Hong-Fu; Yu, Jian-Ming; Sun, Xun
Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 24 p. 6834 - 6837
反应条件
pyridine
T=80°C; 0.5 h;
参考文献
Commercon; Bezard; Bernard; Bourzat
Tetrahedron Letters, 1992 , vol. 33, # 36 p. 5185 - 5188
反应条件
pyridine
T=0 - 20°C;
参考文献
Afon'Kin; Kostrikin; Shumeiko; Popov; Matveev; Matvienko; Zabudkin
Russian Chemical Bulletin, 2012 , vol. 61, # 11 p. 2149 - 2162
Izv. Akad. Nauk, Ser. Khim., 2012 , # 11 p. 2132 - 2145,14
反应条件
pyridine in dichloromethane
T=25 - 30°C; Inert atmosphere;
参考文献
Sekhar; Vishweshwar, Peddy; Acharyulu, Palle V. R.; Anjaneyulu, Yerramilli
Synthetic Communications, 2012 , vol. 42, # 23 p. 3482 - 3492
反应条件
pyridine in dichloromethane
T=25 - 30°C; Inert atmosphere;
参考文献
Sekhar; Vishweshwar, Peddy; Acharyulu, Palle V. R.; Anjaneyulu, Yerramilli
Synthetic Communications, 2012 , vol. 42, # 23 p. 3482 - 3492
