4-溴-2,6-二氨基吡啶合成路线 （共 10 条）
反应条件
1: 4-bromo-pyridine-2,6-dicarbonyl diazide in toluene; tert-butyl alcohol 12 h; Heating / reflux; 2: trifluoroacetic acid in toluene 2 h; Heating / reflux; 3: sodium hydroxide in diethyl ether; water
参考文献
Hoffmann-La Roche Inc.
Patent: US6355653 B1, 2002 ;
Location in patent: Page column 27-28 ;
反应条件
trifluoroacetic acid in dichloromethane
参考文献
Nettekoven
Synlett, 2001 , # 12 p. 1917 - 1920
反应条件
1: With tert-butyl alcohol Heating; 2: With trifluoroacetic acid in dichloromethane
参考文献
Bleicher, Konrad H.; Nettekoven, Matthias; Peters, Jens-Uwe; Wyler, Rene
Chimia, 2004 , vol. 58, # 9 p. 588 - 600
反应条件
1: trifluoroacetic acid; dihydrogen peroxide / water / 5 h / 95 - 100 °C / |Large scale 2: sulfuric acid; nitric acid / 20 h / 60 °C / |Large scale 3: acetyl-bromide / acetic acid / 5 h / 60 - 80 °C 4: toluene / 2 h / 70 °C 5: sulfuric acid / 1.5 h / 40 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 7, # 1 p. 38 - 43
反应条件
1: sulfuric acid; nitric acid / 20 h / 60 °C / |Large scale 2: acetyl-bromide / acetic acid / 5 h / 60 - 80 °C 3: toluene / 2 h / 70 °C 4: sulfuric acid / 1.5 h / 40 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 7, # 1 p. 38 - 43
反应条件
1: acetyl-bromide / acetic acid / 5 h / 60 - 80 °C 2: ammonium hydroxide / water / 3 h / 110 °C / |Sealed tube 3: iron; acetic acid / water / 2 h / 100 °C View Scheme
参考文献
Organic Process Research and Development, , vol. 7, # 1 p. 38 - 43
参考文献
Nettekoven, Matthias; Jenny, Christian
Organic Process Research and Development, 2003 , vol. 7, # 1 p. 38 - 43
反应条件
potassium hydroxide; bromine Hofmann rearrangement; 4 h; Heating;
参考文献
Organic Letters, , vol. 6, # 3 p. 385 - 388
反应条件
ammonium hydroxide T=200°C;
参考文献
Recueil des Travaux Chimiques des Pays-Bas, , vol. 58, p. 1124
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 21, # 11 p. 3237 - 3242
