2,6-二氯-n-甲基-4-嘧啶胺合成路线 (共 7 条)
反应条件
in ethanol 1 h; Ambient temperature;
参考文献
SMITHKLINE BEECHAM CORPORATION
Patent: WO2008/105968 A1, 2008 ;
Location in patent: Page/Page column 66-67 ;
反应条件
N-methylamine hydrochloride; N-ethyl-N,N-diisopropylamine in tetrahydrofuran; hexane; ethyl acetate
参考文献
The Upjohn Company
Patent: US5502187 A1, 1996 ;
参考文献
Winkelmann
Journal fuer Praktische Chemie (Leipzig), 1927 , vol. <2> 115, p. 293
反应条件
1: toluene 2: palladium/charcoal; acetic acid View Scheme
参考文献
King; King
Journal of the Chemical Society, 1947 , p. 726,731
反应条件
phosphorus; hydrogen iodide
参考文献
ICI
Patent: DE839640 , 1949 ;
Full Text Show Details
ICI
Patent: US2585906 , 1949 ;
DRP/DRBP Org.Chem.
反应条件
ethanol
T=170 - 180°C; im Rohr;
参考文献
Winkelmann
Journal fuer Praktische Chemie (Leipzig), 1927 , vol. <2> 115, p. 293
参考文献
Winkelmann
Journal fuer Praktische Chemie (Leipzig), 1927 , vol. <2> 115, p. 293