9-甲基-9H-芴-9-羧酸合成路线 （共 23 条）
反应条件
1: With sodium hydroxide; water in 1,4-dioxane T=20°C; 24 h; 2: With hydrogenchloride in water
参考文献
BOEHRINGER INGELHEIM INTERNATIONAL GMBH; BOEHRINGER INGELHEIM PHARMA GMBH and CO. KG
Patent: WO2005/13999 A1, 2005 ;
Location in patent: Page/Page column 18 ;
反应条件
1: 9-methyl-9H-fluorene With n-butyllithium in tetrahydrofuran; hexane T=-78°C; Inert atmosphere; 2: carbon dioxide in tetrahydrofuran; hexane T=-78 - 20°C;
参考文献
Lindhardt, Anders T.; Simonssen, Roger; Taaning, Rolf H.; Gogsig, Thomas M.; Nilsson, Goeran N.; Stenhagen, Gunnar; Elmore, Charles S.; Skrydstrup, Troels
Journal of Labelled Compounds and Radiopharmaceuticals, 2012 , vol. 55, # 11 p. 411 - 418
反应条件
Irradiation; Further byproducts given;
参考文献
DeCosta, Dayal P.; Pincock, James A.
Journal of the American Chemical Society, 1989 , vol. 111, # 24 p. 8948 - 8950
反应条件
Irradiation; Further byproducts given;
参考文献
DeCosta, Dayal P.; Pincock, James A.
Journal of the American Chemical Society, 1989 , vol. 111, # 24 p. 8948 - 8950
反应条件
1: H2SO4 / Heating 2: NaOMe 3: NaOH / methanol; H2O / Heating View Scheme
参考文献
Rouzaud,J. et al.
Bulletin de la Societe Chimique de France, 1965 , p. 2345 - 2353
反应条件
1: NaOMe 2: NaOH / methanol; H2O / Heating View Scheme
参考文献
Rouzaud,J. et al.
Bulletin de la Societe Chimique de France, 1965 , p. 2345 - 2353
反应条件
1.1: acetic acid / Reflux 1.2: 760.05 Torr 2.1: n-butyllithium / hexane; tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere 2.2: 20 °C View Scheme
参考文献
AARHUS UNIVERSITET; SKRYDSTRUP, Troels; LINDHARDT, Anders Thyboe; HERMANGE, Philippe; TAANING, Rolf Hejle; FRIIS, Stig Duering
Patent: WO2012/79583 A1, 2012 ;
反应条件
2.1: acetic acid / Reflux 2.2: 760.05 Torr 3.1: n-butyllithium / hexane; tetrahydrofuran / 0.17 h / -78 °C / Inert atmosphere 3.2: 20 °C View Scheme
参考文献
AARHUS UNIVERSITET; SKRYDSTRUP, Troels; LINDHARDT, Anders Thyboe; HERMANGE, Philippe; TAANING, Rolf Hejle; FRIIS, Stig Duering
Patent: WO2012/79583 A1, 2012 ;
反应条件
potassium-sodium 1.) Et2O, reflux, 1 h; 2.) Et2O, -75 deg C; Multistep reaction;
参考文献
Grovenstein Jr., Erling; Singh, Jagvir; Patil, Bhalchandra B.; VanDerveer, Don
Tetrahedron, 1994 , vol. 50, # 20 p. 5971 - 5998
反应条件
diethyl ether; sodium Einleiten von Kohlendioxid in die Reaktionsloesung;
参考文献
Wieland; Probst
Justus Liebigs Annalen der Chemie, 1937 , vol. 530, p. 274,289
