1-三苯甲基咪唑-4-甲醛合成路线 （共 31 条）
反应条件
acetic acid in methanol 7 h; Heating;
参考文献
Kirk, Kenneth L.
Journal of Heterocyclic Chemistry, 1985 , vol. 22, p. 57 - 59
反应条件
1.1: NaNH2 / tetrahydrofuran 1.2: 92 percent / tetrahydrofuran / 20 °C 2.1: 98 percent / H2 / Pd/C / 20 °C / 11250.9 Torr 3.1: LiAlH4; AlCl3 / tetrahydrofuran; diethyl ether / 20 °C View Scheme
参考文献
Bertinaria, Massimo; Di Stilo, Antonella; Tosco, Paolo; Sorba, Giovanni; Poli, Enzo; Pozzoli, Cristina; Coruzzi, Gabriella; Fruttero, Roberta; Gasco, Alberto
Bioorganic and Medicinal Chemistry, 2003 , vol. 11, # 7 p. 1197 - 1205
反应条件
in dichloromethane T=-78 - 20°C; 2 - 2.41667 h;
参考文献
Perez, Michel; Lamothe, Marie; Hill, Bridget; Etievant, Chantal
Patent: US2004/204417 A1, 2004 ;
Location in patent: Page 47-48 ;
US 20040204417 A1
反应条件
in acetonitrile T=20 - 60°C; Inert atmosphere;
参考文献
Suryadevara, Praveen Kumar; Olepu, Srinivas; Lockman, Jeffrey W.; Ohkanda, Junko; Karimi, Mandana; Verlinde, Christophe L. M. J.; Kraus, James M.; Schoepe, Jan; Van Voorhis, Wesley C.; Hamilton, Andrew D.; Buckner, Frederick S.; Gelb, Michael H.
Journal of Medicinal Chemistry, 2009 , vol. 52, # 12 p. 3703 - 3715
反应条件
1: 1.) NaH, DMSO / 1.) 70 deg C, 1 h, 2.) 50 deg C, 24 h 2: 1.) H2SO4, 2.) 1N aq. NaOH, 3.) H2 / 3.) 10percent Pd/C View Scheme
参考文献
Bioorganic and Medicinal Chemistry, , vol. 5, # 10 p. 1989 - 1998
反应条件
1.1: n-butyllithium; Di-n-butylmagnesium / hexane; tetrahydrofuran / 1.5 h / -11 - 20 °C / Inert atmosphere 1.2: 7.5 h / -11 °C 2.1: manganese(IV) oxide / isobutyramide / 60 h / 25 °C / Inert atmosphere View Scheme
参考文献
TAKEDA PHARMACEUTICAL COMPANY LIMITED; KAWABATA, Yoichi; SAWAI, Yasuhiro; KANNO, Kazuaki; SAWADA, Naotaka
Patent: WO2012/173280 A1, 2012 ;
反应条件
1: 54 percent / NaH / tetrahydrofuran / Ambient temperature 2: 96 percent / 1 N NaOH / dioxane / 4 h / Ambient temperature View Scheme
参考文献
Sellier, Christian; Buschauer, Armin; Elz, Sigurd; Schunack, Walter
Liebigs Annalen der Chemie, 1992 , # 4 p. 317 - 324
反应条件
1: 1.) magnesium, iodine / 1.) THF, reflux, 1 h, 2.) r.t., THF, 1.5 h 2: 90 percent / MnO2 / dioxane / 5 h / Heating View Scheme
参考文献
Cordi, Alex A.; Persigand, Thierry; Lecouve, Jean-Pierre
Synthetic Communications, 1996 , vol. 26, # 8 p. 1585 - 1593
反应条件
1: 98 percent / tetrahydrofuran; diethyl ether / 1 h 2: 85 percent / manganese(IV) oxide / CH2Cl2 / 12 h / 20 °C View Scheme
参考文献
Matsunaga, Nobuyuki; Kaku, Tomohiro; Itoh, Fumio; Tanaka, Toshimasa; Hara, Takahito; Miki, Hiroshi; Iwasaki, Masahiko; Aono, Tetsuya; Yamaoka, Masuo; Kusaka, Masami; Tasaka, Akihiro
Bioorganic and medicinal chemistry, 2004 , vol. 12, # 9 p. 2251 - 2273
反应条件
potassium dihydrogenphosphate in water
参考文献
University of Pittsburgh
Patent: US2002/193596 A1, 2002 ;
