苄氧羰基-L-脯氨酸 4-硝基苯基酯合成路线 （共 14 条）
反应条件
triethylamine in N,N-dimethyl-formamide
18 h; Ambient temperature;
参考文献
Gray, C. J.; Boukouvalas, J.; Barker, S. A.
Tetrahedron, 1982 , vol. 38, # 10 p. 1465 - 1470
反应条件
1: 96 percent / various solvent(s) / 48 h
2: 1.) H2 / 1.) Pd-C / 1.) methanol, 2.) DMFA, 1 d
3: 1.) H2 / 1.) Pd-C / 1.) methanol, 2.) DMFA, 2 d
4: 80 percent / HBr / trifluoroacetic acid / 0.33 h
View Scheme
参考文献
Lavretskaya, E. F.; Ashmarin, I. P.; Kalikhevich, V. N.; Chamorovskaya, L. T.; Balaban, P. M.; et. al.
Pharmaceutical Chemistry Journal, 1981 , vol. 15, # 1 p. 1 - 3
Khimiko-Farmatsevticheskii Zhurnal, 1981 , vol. 15, # 1 p. 20 - 23
反应条件
sodium hydroxide in 1,4-dioxane
24 h; Ambient temperature;
参考文献
Anokhina, V. V.; Sorochinskaya, E. I.; Golubovich, V. P.; Kinarskii, L. I.; Martynov, V. F.
J. Gen. Chem. USSR (Engl. Transl.), 1990 , vol. 60, # 1.2 p. 203 - 211,178 - 184
反应条件
3: H(1+)
5: hydrogen bromide / acetic acid
7: H2 / catalytic hydrog.
View Scheme
参考文献
Nikolaev, S. V.; Martinov, V. F.
Chemistry of Natural Compounds, 1985 , vol. 21, # 2 p. 269 - 270
Khimiya Prirodnykh Soedinenii, 1985 , # 2 p. 281 - 282
