3-苯基-5-(噻吩-2-基)-[1,2,4]噁二唑合成路线 （共 4 条）
反应条件
tetra(n-butyl)ammonium hydroxide; sodium hydroxide in 2-methyl tetrahydrofuran; water T=70°C; 1.33333 h; SolventTemperatureTimeReagent/catalyst;
参考文献
MONSANTO TECHNOLOGY LLC; MILLER, William Harold; GRAHAM, Charles Richard; BROWN, David Louis
Patent: WO2014/8257 A2, 2014 ;
Location in patent: Paragraph 0036 ;
反应条件
phosphorous acid trimethyl ester in benzene 2 h; Reflux;
参考文献
Memeo, Misal Giuseppe; Dondi, Daniele; Mannucci, Barbara; Corana, Federica; Quadrelli, Paolo
Tetrahedron, 2013 , vol. 69, # 35 p. 7387 - 7394
反应条件
1: hydroxylamine hydrochloride; sodium hydroxide / methanol / 2 h / 55 - 60 °C 2: sodium hydroxide; tetra(n-butyl)ammonium hydroxide / 2-methyl tetrahydrofuran; water / 1.33 h / 70 °C View Scheme
参考文献
MONSANTO TECHNOLOGY LLC; MILLER, William Harold; GRAHAM, Charles Richard; BROWN, David Louis
Patent: WO2014/8257 A2, 2014 ;
反应条件
1: triethylamine / dichloromethane / 48 h / 20 °C 2: phosphorous acid trimethyl ester / benzene / 2 h / |Reflux View Scheme
参考文献
Memeo, Misal Giuseppe; Dondi, Daniele; Mannucci, Barbara; Corana, Federica; Quadrelli, Paolo
Tetrahedron, 2013 , vol. 69, # 35 p. 7387 - 7394
