反应条件
1: H2 / Pd-C 2: benzoyl peroxide 3: HCl / acetonitrile 4: N-iodosuccinimide, 4 Angstroem sieves / CH2Cl2; tetrahydrofuran 5: H2 / Pd-C / ethyl acetate / 2.5 h / 3102.9 Torr / Ambient temperature 6: bovine intestinal alkaline phosphatase 7: benzoyl peroxide / acetonitrile / 2 h / 0 °C 8: N-iodosuccinimide, 4 Angstroem sieves / CH2Cl2; tetrahydrofuran 9: H2 / Pd-C / ethyl acetate / 2.5 h / 3102.9 Torr / Ambient temperature 10: bovine intestinal alkaline phosphatase, or incubation in mouse plasma at 37 deg C View Scheme
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 6, # 15 p. 1837 - 1842
