tetrakis(triphenylphosphine) palladium(0); tripotassium phosphate monohydrate in 1,4-dioxane; water 24 h; Inert atmosphereReflux;

T=180°C; 4 h;

hydrogenchloride; formic acid; water 0.5 h; Heating / reflux;

1.1: thionyl chloride / 1 h / |Reflux 1.2: -10 - 20 °C 2.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran; acetonitrile; methanol / 48 h / 0 - 20 °C / |Inert atmosphere 3.1: hydrazine hydrate / ethanol / 1 h 4.1: 4 h / 180 °C / |Inert atmosphere View Scheme

1: hydrazine hydrate / ethanol / 1 h 2: 4 h / 180 °C / |Inert atmosphere View Scheme