反应条件
1: tetrakis(triphenylphosphine) palladium(0); sodium carbonate / ethylene glycol dimethyl ether; water / 90 °C
2: N-iodo-succinimide / N,N-dimethyl-formamide
3: trifluoroacetic acid
4: (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium carbonate; 4,4,5,5-tetramethyl-[1,3,2]dioxaborolane / tetrahydrofuran; methanol; water / 80 °C
View Scheme
参考文献
Curtin, Michael L.; Frey, Robin R.; Heyman, H. Robin; Soni, Niru B.; Marcotte, Patrick A.; Pease, Lori J.; Glaser, Keith B.; Magoc, Terrance J.; Tapang, Paul; Albert, Daniel H.; Osterling, Donald J.; Olson, Amanda M.; Bouska, Jennifer J.; Guan, Zhiwen; Preusser, Lee C.; Polakowski, James S.; Stewart, Kent D.; Tse, Chris; Davidsen, Steven K.; Michaelides, Michael R.
Bioorganic and Medicinal Chemistry Letters, 2012 , vol. 22, # 9 p. 3208 - 3212