1: 35 percent / Mg; CuBr*SMe2 2: 63 percent / EDC; HOBt; N-ethylmorpholine 3: LiOH 4: 61 percent / EDC; HOBt; N-ethylmorpholine 5: LiOH 6: aq. HCl / acetic acid 7: pentafluorophenyl diphenylphosphinate; N-ethylmorpholine / dimethylformamide 8: TBAF; MS 4A / tetrahydrofuran / 24 h 9: 88 percent / TPAP; NMO; MS 4A / CH2Cl2 View Scheme