2-苯基-4-氯-5-氰基嘧啶合成路线 （共 3 条）
反应条件
N,N-dimethyl-aniline; trichlorophosphate 1 h; Heating / reflux;
参考文献
VERTEX PHARMACEUTICALS INCORPORATED
Patent: WO2005/3099 A2, 2005 ;
Location in patent: Page 129-130 ;
WO 2005/003099 A2
反应条件
hydrogenchloride; ethanol 1) standing overnight in refrigerator 2) ethanol, NH3, 5 h, 20 deg C; Yield given. Multistep reaction. Yields of byproduct given;
参考文献
Mamaev, V. P.; Mikhaleva, M. A.; Shadrina, A. I.
Chemistry of Heterocyclic Compounds (New York, NY, United States), 1988 , p. 303 - 307
Khimiya Geterotsiklicheskikh Soedinenii, 1988 , vol. 24, # 3 p. 371 - 375
反应条件
zinc in ethanol; water
Heating;
参考文献
Baram, S. G.; Shkurko, O. P.; Mamaev, V. P.
Bulletin of the Academy of Sciences of the USSR, Division of Chemical Science (English Translation), 1983 , vol. 32, # 2 p. 265 - 270
Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, 1983 , # 2 p. 299 - 304
