N-(5-氯-2-吡啶基)-2-[(4-氰基苯甲酰基)氨基]-5-甲氧基苯甲酰胺合成路线 (共 2 条)
反应条件
1: dimethyl amine With n-hexyl lithium in tetrahydrofuran; hexane T=8 - 12°C; 3 h; 2: N-(5-chloro(2-pyridyl)){2-[(4-cyanophenyl)carbonylamino]-5-methoxyphenyl}-carboxamide in tetrahydrofuran; hexane T=-12 - -8°C; 3: With sodium hydrogencarbonate; sodium carbonate in water T=-8 - 25°C;
参考文献
WO2012/31017 A1, ;
Page/Page column 44 ;
反应条件
in tetrahydrofuran; hexane T=0 - 20°C;
参考文献
Bioorganic and Medicinal Chemistry Letters, , vol. 19, # 8 p. 2179 - 2185