hydrogenchloride in 1,4-dioxane 1.5 h;

<b>With</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '3587189', constants.ctx, '0')">hydrogen</a>;&nbsp;<a href="#" onclick="return RXDsubstances(event, this, '11378922', constants.ctx, '0')">palladium on activated charcoal</a>&nbsp;<b>in</b>&nbsp; <a href="#" onclick="return RXDsubstances(event, this, '1098229', constants.ctx, '0')">methanol</a> <br /> <br /> &nbsp;

<b>Multi-step reaction with 2 steps<br /> </b>1: morph-DAST / tetrahydrofuran / -78 - 20 &deg;C<br />2: H₂ / Pd/C / methanol<br /> <br /> &nbsp;

<b>Multi-step reaction with 4 steps<br /> </b>1.1: aq. NaOH / tetrahydrofuran / 1 h<br />2.1: Cs₂CO₃ / dimethylformamide / 0 &deg;C<br />2.2: 5.3 g / dimethylformamide / 20 &deg;C<br />3.1: morph-DAST / tetrahydrofuran / -78 - 20 &deg;C<br />4.1: H₂ / Pd/C / methanol<br /> <br /> &nbsp;

<b>Multi-step reaction with 7 steps<br /> </b>1.1: 80 percent / aq. NaOH / tetrahydrofuran<br />2.1: diethyl ether<br />3.1: PPh₃P; diisopropyl azodicarboxylate / tetrahydrofuran / 3 h<br />4.1: aq. NaOH / tetrahydrofuran / 1 h<br />5.1: Cs₂CO₃ / dimethylformamide / 0 &deg;C<br />5.2: 5.3 g / dimethylformamide / 20 &deg;C<br />6.1: morph-DAST / tetrahydrofuran / -78 - 20 &deg;C<br />7.1: H₂ / Pd/C / methanol<br /> <br /> &nbsp;