反应条件
1: sodium hydroxide / 1 h / 0 °C
2: thionyl chloride; N,N-dimethyl-formamide / 4 h / |Reflux
3: organic base / dichloromethane / 12 h / 20 °C
4: 1-methylguanidine hydrochloride; triethylamine / dichloromethane; methanol / 20 °C / |Inert atmosphere
View Scheme
参考文献
Sanderson, J. Thomas; Clabault, Helene; Patton, Cody; Lassalle-Claux, Gregoire; Jean-Francois, Jacques; Pare, Aurelie F.; Hebert, Martin J.G.; Surette, Marc E.; Touaibia, Mohamed
Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 22 p. 7182 - 7193
