2-氟-4-甲氧基苯甲醛合成路线 （共 36 条）
反应条件
potassium hydrogensulfate; triethylamine in dimethyl sulfoxide
参考文献
Sumitomo Pharmaceuticals Co., Ltd.
Patent: US6194461 B1, 2001 ;
反应条件
1: 1-bromo-2-fluoro-4-methoxybenzene With n-butyllithium in tetrahydrofuran; hexane T=-78°C; 0.5 h; 2: N,N-dimethyl-formamide in tetrahydrofuran; hexane T=-78 - 0°C; 1 h;
参考文献
EP1813611 A1, ;
Page/Page column 23 ;
反应条件
potassium fluoride in N,N-dimethyl-formamide 18 h; Ambient temperature;
参考文献
Monclus, Michel; Masson, Carine; Luxen, Andre
Journal of Fluorine Chemistry, 1995 , vol. 70, # 1 p. 39 - 44
反应条件
1: 1-bromo-2-fluoro-4-methoxybenzene With tert.-butyl lithium in tetrahydrofuran; pentane T=-78°C; 0.5 h; Inert atmosphere; 2: N,N-dimethyl-formamide in tetrahydrofuran; pentane T=-78 - 20°C; Inert atmosphere;
参考文献
Synthesis, , # 12 art. no. T20108SS, p. 2040 - 2060
反应条件
1: 95 percent / imidazole / dimethylformamide / Ambient temperature 2: 1.) 1.4M sec-butyllithium / 1.) THF, cyclohexane, 30 min at -78 deg C; 2.) THF, cyclohexane, 30 min at room temp. 3: 85 percent / KF / dimethylformamide / 18 h / Ambient temperature View Scheme
参考文献
Journal of Fluorine Chemistry, , vol. 70, # 1 p. 39 - 44
反应条件
1: 1.) 1.4M sec-butyllithium / 1.) THF, cyclohexane, 30 min at -78 deg C; 2.) THF, cyclohexane, 30 min at room temp. 2: 85 percent / KF / dimethylformamide / 18 h / Ambient temperature View Scheme
参考文献
Journal of Fluorine Chemistry, , vol. 70, # 1 p. 39 - 44
反应条件
n-butyllithium; bromine; iron 1.) CCl4, -60 deg C, 2 h, 2.) Et2O, -55 deg C; Yield given. Multistep reaction;
参考文献
Journal of Medicinal Chemistry, , vol. 31, # 1 p. 72 - 83
反应条件
potassium carbonate; xylene
参考文献
Journal of the Chemical Society, , p. 1639
反应条件
Multistep reaction. Yields of byproduct given;
参考文献
Archiv der Pharmazie, , vol. 327, # 9 p. 547 - 561
反应条件
Yield given. Multistep reaction;
参考文献
Archiv der Pharmazie, , vol. 327, # 9 p. 547 - 561
