2-氟-4-甲氧基苯甲醛合成路线 （共 36 条）
反应条件
1: boron tribromide / dichloromethane / 3.25 h / 0 - 20 °C
2: bromine / acetic acid / 26 h / 45 °C
View Scheme
参考文献
LIGAND PHARMACEUTICALS INC.; SMITHKLINE BEECHAM CORPORATION; MCGUINNESS, Brian, F.; HO, Koc-kan; BABU, Suresh; DONG, Guizhen; DUO, Jingqi; LE, Thuy, X., H.; SAIONZ, Kurt, W.; NEEB, Michael, J.
Patent: WO2011/2814 A2, 2011 ;
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene in N,N-dimethyl-formamide
T=20 - 60°C;
参考文献
TRIGEN LIMITED
Patent: WO2007/96362 A1, 2007 ;
Location in patent: Page/Page column 231-232 ;
WO 2007/096362 A1
反应条件
1.1: 96 percent / NaBH4 / methanol / 3.5 h / 0 - 20 °C
2.1: carbon tetrabromide; triphenylphosphine / CH2Cl2 / 3 h / 20 °C
2.2: 55 percent / sodium hydride / tetrahydrofuran / 8 h / 0 - 20 °C
View Scheme
参考文献
Kim, Young Ah; Sharon, Ashoke; Chu, Chung K.; Rais, Reem H.; Al Safarjalani, Omar N.; Naguib, Fardos N.M.; el Kouni, Mahmoud H.
Biochemical Pharmacology, 2007 , vol. 73, # 10 p. 1558 - 1572
反应条件
potassium bromide; bromine in water
T=0 - 20°C; 3 h;
参考文献
Kyowa Hakko Kirin Co., Ltd.
Patent: EP2269993 A1, 2011 ;
Location in patent: Page/Page column 51 ;
反应条件
triethylamine in N,N-dimethyl-formamide
T=100°C; 72 h;
参考文献
Branum, Shawn T.; Colburn, Raymond W.; Dax, Scott L.; Flores, Christopher M.; Jetter, Michele C.; Liu, Yi; Ludovici, Donald; Macielag, Mark J.; Matthews, Jay M.; McNally, James J.; Reaney, Laura M.; Russell, Ronald K.; Qin, Ning; Teleha, Christopher; Wells, Kenneth M.; Youells, Scott C.; Youngman, Mark A.
Patent: US2012/190674 A1, 2012 ;
Location in patent: Page/Page column 87 ;
反应条件
1: 83 percent / NaBH4 / methanol / 0.5 h / Ambient temperature
2: 95 percent / pyridine, SOBr2 / CH2Cl2 / 3 h / Heating
View Scheme
参考文献
Monclus, Michel; Masson, Carine; Luxen, Andre
Journal of Fluorine Chemistry, 1995 , vol. 70, # 1 p. 39 - 44
