4-氨基-4-氰基-哌啶-1-羧酸叔丁酯合成路线 (共 7 条)
反应条件
1: tert-butyl 4-oxo-piperidine-1-carboxylate With ammonium chloride in methanol T=20°C; 1 h; 2: sodium cyanide in methanol 16 h;
参考文献
Degnan, Andrew P.; Han, Xiaojun; Dubowchik, Gene M.; Macor, John E.; Mercer, Stephen E.
Patent: US2005/215576 A1, 2005 ;
Location in patent: Page/Page column 19 ;
US 20050215576 A1
反应条件
1: tert-butyl 4-oxo-piperidine-1-carboxylate With ammonium chloride in methanol T=20°C; 1 h; 2: sodium cyanide in methanol 16 h;
参考文献
BRISTOL-MYERS SQUIBB COMPANY
Patent: WO2003/104236 A1, 2003 ;
Location in patent: Page 58 ;
WO 03/104236 A1
反应条件
ammonium acetate in methanol T=20°C;
参考文献
IRM LLC
Patent: WO2005/107464 A2, 2005 ;
Location in patent: Page/Page column 33 ;
WO 2005/107464 A2
反应条件
ammonium chloride in methanol
参考文献
Chaturvedula, Prasad V.; Chen, Ling; Civiello, Rita; Conway, Charles Mark; Degnan, Andrew P.; Dubowchik, Gene M.; Han, Xiaojun; J. Jiang, Xiang Jun; Karageorge, George N.; Luo, Guanglin; Macor, John E.; Poindexter, Graham; Tora, George; Vig, Shikha
Patent: US2004/204397 A1, 2004 ;
US 20040204397 A1
反应条件
NaCN; ammonium chloride; ammonia in methanol; dichloromethane
反应条件
trifluoroacetic anhydride in pyridine; 4-(dicyanomethylene)-2-methyl-6-(4-dimethylaminostyryl)-4H-pyran; Petroleum ether
参考文献
Vertex Pharmaceuticals Incorported
Patent: US2011/98311 A1, 2011 ;
反应条件
1: pyridine / methanol / 18 h / 0 °C 2: H2 / Raney-Ni / ethanol / 18 h / 20 °C 3: 88 percent / pyridine / 18 h / 0 °C 4: NH3 / methanol / 18 h / Heating View Scheme
参考文献
Kim, In Ho; Combrink, Keith D.; Ma, Zhenkun; Chapo, Katrina; Yan, Dalai; Renick, Paul; Morris, Timothy W.; Pulse, Mark; Simecka, Jerry W.; Ding, Charles Z.
Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 5 p. 1181 - 1184