4-[(1,1-二甲基丙基-2-基)氧基]苯甲腈合成路线 （共 16 条）
反应条件
1,8-diazabicyclo[5.4.0]undec-7-ene; copper(l) chloride in acetonitrile T=0°C; 2.5 h; variation of conditions; other solvents; further phenols; further copper (Cu(II)) catalyst; further 2-substituted-2-methyl-3-butynes; Product distribution;
参考文献
Tetrahedron Letters, , vol. 35, # 35 p. 6405 - 6408
反应条件
1: n-butyl lithium 2: 86 percent / 0.3 mole percent CuCl2 * 2 H2O, 1,8-diazabicyclo<5.4.0>undec-7-ene / acetonitrile / 24 h / 0 °C View Scheme
参考文献
Tetrahedron Letters, , vol. 35, # 35 p. 6405 - 6408
反应条件
T=220°C; 0.0583333 h; Flow reactorLarge scale; Temperature;
参考文献
Bogaert-Alvarez, Ricardo J.; Demena, Paul; Kodersha, Gus; Polomski, Robert E.; Soundararajan; Wang, Steve S. Y.
Organic Process Research and Development, 2001 , vol. 5, # 6 p. 636 - 645
反应条件
1: various solvent(s) / Heating 2: N-bromosuccinimide (NBS), H2O / dimethylsulfoxide / 0.5 h View Scheme
参考文献
Journal of Medicinal Chemistry, 1983 , vol. 26, # 11 p. 1582 - 1589
反应条件
1: 88 percent / PdCl2 2: 30 percent / various solvent(s) / 5 h / 165 °C 3: 43 percent / m-chloroperbenzoic acid / CH2Cl2 View Scheme
参考文献
Attwood, Michael R.; Churcher, Ian; Dunsdon, Rachel M.; Hurst, David N.; Jones, Philip S.
Tetrahedron Letters, 1991 , vol. 32, # 6 p. 811 - 814
反应条件
1: N,N-dimethyl-aniline / 4 h / 200 °C / |Inert atmosphere
2: MnII(OTf)2; acetic acid; dihydrogen peroxide; C32H38N4O2 / acetonitrile / 0 - 20 °C / |Inert atmosphere
3: sodium hydride / dimethyl sulfoxide / 4 h / 25 °C / |Inert atmosphere
View Scheme
参考文献
Dai, Wen; Li, Jun; Li, Guosong; Yang, Hua; Wang, Lianyue; Gao, Shuang
Organic Letters, 2013 , vol. 15, # 16 p. 4138 - 4141
