1: malonic acid ethyl ester monopotassium salt With magnesium chloride in acetonitrile T=35°C; 0.75 h; 2: With triethylamine in acetonitrile T=25°C; 0.5 h; 3: 1-(3-fluorobenzoyl) imidazole With hydrogenchloride; water more than 3 stages;
1.1: acetonitrile / 4 h / 20 °C / Large scale reaction 2.1: magnesium chloride / acetonitrile / 20 °C / Large scale reaction 2.2: 20 °C / Large scale reaction 2.3: 20 °C / Large scale reaction View Scheme
参考文献
Organic Process Research and Development, , vol. 16, # 2 p. 214 - 219
