4-氯-5-甲氧基-3-喹啉甲腈合成路线 （共 3 条）
反应条件
1.1: 2 h / Heating 2.1: n-BuLi / tetrahydrofuran; hexane / 0.25 h / -78 °C 2.2: tetrahydrofuran / 4.5 h / -78 - 20 °C 2.3: AcOH / tetrahydrofuran / 20 °C 3.1: 772 mg / POCl3; DMF / 4 h / Heating View Scheme
参考文献
Boschelli; Wang; Ye; Wu; Zhang; Dutia; Powell; Wissner; Arndt; Weber
Journal of Medicinal Chemistry, 2001 , vol. 44, # 5 p. 822 - 833
反应条件
trichlorophosphate Heating;
参考文献
Boschelli; Wang; Ye; Wu; Zhang; Dutia; Powell; Wissner; Arndt; Weber
Journal of Medicinal Chemistry, 2001 , vol. 44, # 5 p. 822 - 833
反应条件
1.1: Heating 2.1: tetrahydrofuran / -78 °C 2.2: AcOH / 20 °C 3.1: POCl3 / Heating View Scheme
参考文献
Zhang, Nan; Wu, Biqi; Powell, Dennis; Wissner, Allan; B. Floyd, Middleton; D. Kovacs, Eleonora; Toral-Barza, Lourdes; Kohler, Constance
Bioorganic and Medicinal Chemistry Letters, 2000 , vol. 10, # 24 p. 2825 - 2828
