1: With water; sodium hydroxide in tetrahydrofuran; methanol T=20°C; 1.5 h; 2: With hydrogenchloride in tetrahydrofuran; methanol; water pH=~ 1;

1.1: sodium carbonate / di-μ-chloro-bis(η4-1,5-cyclooctadiene)diiridium / toluene / 100 °C / Inert atmosphere 2.1: diethylzinc / 1,2-dichloro-ethane / 0 - 20 °C 3.1: sodium hydroxide; water / tetrahydrofuran; methanol / 1.5 h / 20 °C 3.2: pH ~ 1 View Scheme

1.1: diethylzinc / 1,2-dichloro-ethane / 0 - 20 °C 2.1: sodium hydroxide; water / tetrahydrofuran; methanol / 1.5 h / 20 °C 2.2: pH ~ 1 View Scheme