2',4'-二氟-4-联苯基羧酸合成路线 （共 4 条）
反应条件
1: With sodium hydroxide; water in tetrahydrofuran T=40°C; 72 h; 2: With hydrogenchloride in water pH=2;
参考文献
ELI LILLY AND COMPANY
Patent: WO2006/66173 A2, 2006 ;
Location in patent: Page/Page column 75 ;
WO 2006/066173 A2
反应条件
hydrogenchloride; lithium hydroxide in tetrahydrofuran; water
参考文献
Aventis Pharma Deutschland GmbH
Patent: US2004/220191 A1, 2004 ;
反应条件
1: Pd(PPh3)4; aq. Na2CO3 / toluene; ethanol / 25 h / 70 °C 2: aq. LiOH / tetrahydrofuran; methanol / 4 h / 20 °C View Scheme
参考文献
Adamski-Werner, Sara L.; Palaninathan, Satheesh K.; Sacchettini, James C.; Kelly, Jeffery W.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 2 p. 355 - 374
反应条件
1: Pd(PPh3)4; aq. Na2CO3 / toluene; ethanol / 25 h / 70 °C 2: aq. LiOH / tetrahydrofuran; methanol / 4 h / 20 °C View Scheme
参考文献
Adamski-Werner, Sara L.; Palaninathan, Satheesh K.; Sacchettini, James C.; Kelly, Jeffery W.
Journal of Medicinal Chemistry, 2004 , vol. 47, # 2 p. 355 - 374
