2,2,5-三甲基-1,3-二恶烷-5-甲酰氯合成路线 (共 4 条)
参考文献
American Home Products Corporation
Patent: US6277983 B1, 2001 ;
参考文献
Giri, Ramesh; Chen, Xiao; Yu, Jin-Quan
Angewandte Chemie - International Edition, 2005 , vol. 44, # 14 p. 2112 - 2115
反应条件
1: pyridine / dichloromethane / 24 h / 5 °C 2: water; sulfuric acid / tetrahydrofuran / 24 h / 5 °C View Scheme
参考文献
SANDOZ AG; FELZMANN, Wolfgang; SCHOeNE, Niklas
Patent: WO2012/131019 A1, 2012 ;
→
162635-03-2(1R,2R,4S)-4-{(2R)-2-[(1R,9S,12S,15R,16E,18R,19R,21R,23S,24E,26E,28E,30S,32S,35R)-1,18-二羟基-19,30-二甲氧基-15,17,21,23,29,35-六甲基-2,3,10,14,20-五氧代-11,36-二氧杂-4-氮杂三环[30.3.1.04,9]三十六碳-16,24,26,28-四烯-12-基]丙基}-2-甲氧基环己基2,2,5-三甲基-1,3-二恶烷-5-羧酸酯
反应条件
pyridine in dichloromethane T=5°C; 24 h; Product distribution / selectivity;
参考文献
SANDOZ AG; FELZMANN, Wolfgang; SCHOeNE, Niklas
Patent: WO2012/131019 A1, 2012 ;
Location in patent: Page/Page column 8-9 ;