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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
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乙二醇
甲醛
63148-62-9
MDI
丁酮
二甲基亚砜
碳酸氢钠
471-34-1
33187-98-3
合成路线
(共 14 条)
140464-79-5
→
反应条件
33187-98-3
反应条件
acetic acid in water 5 h; Heating;
参考文献
Azzena, Ugo; Melloni, Giovanni; Piroddi, Anna Maria; Azara, Emanuela; Contini, Stefania; Fenude, Emma
Journal of Organic Chemistry, 1992 , vol. 57, # 11 p. 3101 - 3106
55687-80-4
→
反应条件
33187-98-3
反应条件
acetic acid in water 5 h; Heating;
参考文献
Azzena, Ugo; Melloni, Giovanni; Piroddi, Anna Maria; Azara, Emanuela; Contini, Stefania; Fenude, Emma
Journal of Organic Chemistry, 1992 , vol. 57, # 11 p. 3101 - 3106
59276-37-8
3,4,5-三甲氧基苯甲醛二甲基缩醛
→
反应条件
33187-98-3
反应条件
1: 1) Na / 1) THF, 24h, r.t., 2) THF, 3h, -40 deg C 2: AcOH / H2O / 5 h / Heating View Scheme
参考文献
Azzena, Ugo; Melloni, Giovanni; Piroddi, Anna Maria; Azara, Emanuela; Contini, Stefania; Fenude, Emma
Journal of Organic Chemistry, 1992 , vol. 57, # 11 p. 3101 - 3106
101403-71-8
→
反应条件
33187-98-3
反应条件
1: 1) Na / 1) THF, 24h, r.t., 2) THF, 3h, -40 deg C 2: AcOH / H2O / 5 h / Heating View Scheme
参考文献
Azzena, Ugo; Melloni, Giovanni; Piroddi, Anna Maria; Azara, Emanuela; Contini, Stefania; Fenude, Emma
Journal of Organic Chemistry, 1992 , vol. 57, # 11 p. 3101 - 3106
33187-98-3
→
反应条件
74731-65-0
反应条件
1: 81 percent / sodium methylate / dimethylformamide / 0.25 h / 75 °C 2: 95 percent / propan-2-ol / 0.5 h / Heating 3: 86 percent / sodium methylate / ethanol / 40 h / Heating 4: 1.) sodium hydride / 1.) DMF, 45 min, 65 deg C; 2.) THF-DMF, 60 deg C, 20 min 5: 58 percent / amalgamated alumina / tetrahydrofuran; H2O / 5 h / 60 °C 6: 80 percent / hydroxylamine hydrochloride, pyridine / ethanol / 4 h / Heating View Scheme
参考文献
Kompis; Then; Boehni; et al.
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 1 p. 17 - 22
55720-60-0
+
33187-98-3
+
50-01-1
盐酸胍
+
107-13-1
丙烯腈
→
反应条件
55687-40-6
反应条件
in methanol; water; acetic acid
参考文献
Hoffmann-La Roche Inc.
Patent: US3931181 A1, 1976 ;
33187-98-3
→
反应条件
55687-40-6
反应条件
1: 81 percent / sodium methylate / dimethylformamide / 0.25 h / 75 °C 2: 95 percent / propan-2-ol / 0.5 h / Heating 3: 86 percent / sodium methylate / ethanol / 40 h / Heating View Scheme
参考文献
Kompis; Then; Boehni; et al.
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 1 p. 17 - 22
33187-98-3
→
反应条件
55687-45-1
反应条件
1: 81 percent / sodium methylate / dimethylformamide / 0.25 h / 75 °C 2: 95 percent / propan-2-ol / 0.5 h / Heating 3: 86 percent / sodium methylate / ethanol / 40 h / Heating 4: 67 percent / dimethylamine / methanol; H2O / 16 h / 160 °C View Scheme
参考文献
Kompis; Then; Boehni; et al.
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 1 p. 17 - 22
33187-98-3
→
反应条件
55687-47-3
反应条件
1: 81 percent / sodium methylate / dimethylformamide / 0.25 h / 75 °C 2: 95 percent / propan-2-ol / 0.5 h / Heating 3: 86 percent / sodium methylate / ethanol / 40 h / Heating 4: 61 percent / sodium / ethanol / 48 h / Heating View Scheme
参考文献
Kompis; Then; Boehni; et al.
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 1 p. 17 - 22
33187-98-3
→
反应条件
55687-49-5
[4-[(2,4-二氨基嘧啶-5-基)甲基]-2,6-二甲氧基-苯基]甲醇
反应条件
1: 81 percent / sodium methylate / dimethylformamide / 0.25 h / 75 °C 2: 95 percent / propan-2-ol / 0.5 h / Heating 3: 86 percent / sodium methylate / ethanol / 40 h / Heating 4: 62 percent / dibal-H / dioxane / 1.25 h / 50 °C View Scheme
参考文献
Kompis; Then; Boehni; et al.
European Journal of Medicinal Chemistry, 1980 , vol. 15, # 1 p. 17 - 22
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