乙基3-氯-4H-噻吩并[3,2-b]吡咯-5-羧酸酯合成路线 (共 4 条)
反应条件
copper(l) chloride in N,N-dimethyl-formamide T=140°C; 16 h;
参考文献
SEPRACOR INC.
Patent: US2008/4327 A1, 2008 ;
Location in patent: Page/Page column 42 ;
反应条件
copper(l) chloride in N,N-dimethyl-formamide 16 h; Heating / reflux;
参考文献
MERCK SHARP and DOHME LIMITED; MERCK and CO., INC.
Patent: WO2007/39773 A1, 2007 ;
Location in patent: Page/Page column 19-20 ;
反应条件
in anhydrous xylene 0.5 h; Reflux;
参考文献
Parmentier, Jean-Gilles; Portevin, Bernard; Golsteyn, Roy M.; Pierre, Alain; Hickman, John; Gloanec, Philippe; De Nanteuil, Guillaume
Bioorganic and Medicinal Chemistry Letters, 2009 , vol. 19, # 3 p. 841 - 844
反应条件
1: With potassium hydroxide; water in methanol T=85°C; 3 h; 2: With hydrogenchloride in methanol; water
参考文献
MERCK SHARP and DOHME LIMITED; MERCK and CO., INC.
Patent: WO2007/39773 A1, 2007 ;
Location in patent: Page/Page column 19 ;